Phage therapy targeting DNA-encapsulated membrane vesicle-producing intestinal symbiotic Klebsiella pneumoniae ameliorates autoimmune disease.

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Title: Phage therapy targeting DNA-encapsulated membrane vesicle-producing intestinal symbiotic Klebsiella pneumoniae ameliorates autoimmune disease.
Authors: Pu B; Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Wang R; Department of Immunology, Yale School of Medicine, New Haven, CT, USA.; Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai, China., Wang J; Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Li L; Shanghai Public Health Clinical Center, Fudan University, Shanghai, China., Li J; Shanghai Public Health Clinical Center, Fudan University, Shanghai, China., Cai M; Shanghai Immune Therapy Institute, Renji Hospital & Renji Baoshan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhong Y; Shanghai Immune Therapy Institute, Renji Hospital & Renji Baoshan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Yan B; Center for Tuberculosis Research, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China., Lv L; State Key Laboratory for Oncogenes and Related Genes, Division of Cardiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhang Y; School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Dong K; School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Luo J; Experiment Teaching Center of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Li H; Experiment Teaching Center of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Chen X; Experiment Teaching Center of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhou Q; Experiment Teaching Center of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Liu C; Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Tang R; Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai, China., Ma X; Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai, China., Guo X; School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhao W; Experiment Teaching Center of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zhaowei_sjtu@sjtu.edu.cn., Qin J; Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. jinhongqin@sjtu.edu.cn.
Source: NPJ biofilms and microbiomes [NPJ Biofilms Microbiomes] 2026 Apr 08; Vol. 12 (1). Date of Electronic Publication: 2026 Apr 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101666944 Publication Model: Electronic Cited Medium: Internet ISSN: 2055-5008 (Electronic) Linking ISSN: 20555008 NLM ISO Abbreviation: NPJ Biofilms Microbiomes Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2055-5008
DOI:10.1038/s41522-026-00981-1