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Synthetic super-enhancers enable precision viral immunotherapy.

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Title: Synthetic super-enhancers enable precision viral immunotherapy.
Authors: Koeber U; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; IQVIA RDS, Frankfurt am Main, Germany., Matjusaitis M; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; Plurify, Cambridge, UK., Alfazema N; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK., Furlong K; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Wang Z; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK., White R; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; Trogenix, Edinburgh, UK., Hamdan A; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; Edinburgh Pathology, Royal Infirmary Edinburgh, NHS Lothian, Edinburgh, UK., Dewari P; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK., Morisse G; Cancer Research UK Scotland Centre, Edinburgh, UK.; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK., Navarette M; Immune Regulation and Tumor Immunotherapy Group, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, London, UK., Willis R; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK., Wang J; Cancer Research UK Scotland Centre, Edinburgh, UK.; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK., Clark MP; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; Trogenix, Edinburgh, UK., Jacinto de Sousa C; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; Trogenix, Edinburgh, UK., Hong HI; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK., Sheraz S; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK., Southgate B; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; Trogenix, Edinburgh, UK., Cholewa-Waclaw J; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK., Gogolok S; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK., Morrison GM; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK., Cancino FG; Immune Regulation and Tumor Immunotherapy Group, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, London, UK.; Laboratory of Immune Regulation, NDM Centre for Immuno-Oncology, University of Oxford, Oxford, UK., Robertson F; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK., Williams A; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Rosser SJ; School of Biological Sciences, University of Edinburgh, Edinburgh, UK., Brennan PM; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Sieger D; Cancer Research UK Scotland Centre, Edinburgh, UK.; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK., Soufi A; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Quezada SA; Immune Regulation and Tumor Immunotherapy Group, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, London, UK., Pollard SM; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK. steven.pollard@ed.ac.uk.; Cancer Research UK Scotland Centre, Edinburgh, UK. steven.pollard@ed.ac.uk.
Source: Nature [Nature] 2026 May; Vol. 653 (8113), pp. 232-241. Date of Electronic Publication: 2026 Apr 08.
Publication Type: Journal Article
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  Data: Synthetic super-enhancers enable precision viral immunotherapy.
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  Data: <searchLink fieldCode="AU" term="%22Koeber+U%22">Koeber U</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; IQVIA RDS, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Matjusaitis+M%22">Matjusaitis M</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; Plurify, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Alfazema+N%22">Alfazema N</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Furlong+K%22">Furlong K</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22White+R%22">White R</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; Trogenix, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Hamdan+A%22">Hamdan A</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; Edinburgh Pathology, Royal Infirmary Edinburgh, NHS Lothian, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Dewari+P%22">Dewari P</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Morisse+G%22">Morisse G</searchLink>; Cancer Research UK Scotland Centre, Edinburgh, UK.; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Navarette+M%22">Navarette M</searchLink>; Immune Regulation and Tumor Immunotherapy Group, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Willis+R%22">Willis R</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Cancer Research UK Scotland Centre, Edinburgh, UK.; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Clark+MP%22">Clark MP</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; Trogenix, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Jacinto+de+Sousa+C%22">Jacinto de Sousa C</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; Trogenix, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Hong+HI%22">Hong HI</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Sheraz+S%22">Sheraz S</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Southgate+B%22">Southgate B</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; Trogenix, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Cholewa-Waclaw+J%22">Cholewa-Waclaw J</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Gogolok+S%22">Gogolok S</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Morrison+GM%22">Morrison GM</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Cancino+FG%22">Cancino FG</searchLink>; Immune Regulation and Tumor Immunotherapy Group, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, London, UK.; Laboratory of Immune Regulation, NDM Centre for Immuno-Oncology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Robertson+F%22">Robertson F</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Williams+A%22">Williams A</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Rosser+SJ%22">Rosser SJ</searchLink>; School of Biological Sciences, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Brennan+PM%22">Brennan PM</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Sieger+D%22">Sieger D</searchLink>; Cancer Research UK Scotland Centre, Edinburgh, UK.; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Soufi+A%22">Soufi A</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Quezada+SA%22">Quezada SA</searchLink>; Immune Regulation and Tumor Immunotherapy Group, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Pollard+SM%22">Pollard SM</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK. steven.pollard@ed.ac.uk.; Cancer Research UK Scotland Centre, Edinburgh, UK. steven.pollard@ed.ac.uk.
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