Methylome profiling reveals context-dependent chemo-resistance mechanisms and enhances risk stratification in AML.

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Title: Methylome profiling reveals context-dependent chemo-resistance mechanisms and enhances risk stratification in AML.
Authors: Chai Y; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore., Bono KAM; Centre for Translational Medicine, Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Tang NX; Centre for Translational Medicine, Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Ooi MG; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), The National University Health System (NUHS), 1E, Kent Ridge Road, Singapore, 119228, Singapore., Jen WY; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), The National University Health System (NUHS), 1E, Kent Ridge Road, Singapore, 119228, Singapore., Chan EHL; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), The National University Health System (NUHS), 1E, Kent Ridge Road, Singapore, 119228, Singapore., Lui PL; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), The National University Health System (NUHS), 1E, Kent Ridge Road, Singapore, 119228, Singapore., Ng CH; Centre for Clinical Hematology, Gleneagles Hospital, 6A Napier Road, Singapore, 258500, Singapore., Mohamed JS; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), The National University Health System (NUHS), 1E, Kent Ridge Road, Singapore, 119228, Singapore., Song F; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), The National University Health System (NUHS), 1E, Kent Ridge Road, Singapore, 119228, Singapore., White KP; Centre for Translational Medicine, Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; Department of Biochemistry and Precision Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore, 117596, Singapore., Chng WJ; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore. weejoo.chng@nus.edu.sg.; Centre for Translational Medicine, Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. weejoo.chng@nus.edu.sg.; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), The National University Health System (NUHS), 1E, Kent Ridge Road, Singapore, 119228, Singapore. weejoo.chng@nus.edu.sg.; NUS Centre for Cancer Research (N2CR), Centre for Translational Medicine, 14 Medical Drive, Singapore, 117599, Singapore. weejoo.chng@nus.edu.sg., Zhou J; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore. csizjb@nus.edu.sg.; Centre for Translational Medicine, Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. csizjb@nus.edu.sg.; NUS Centre for Cancer Research (N2CR), Centre for Translational Medicine, 14 Medical Drive, Singapore, 117599, Singapore. csizjb@nus.edu.sg.
Source: Cancer cell international [Cancer Cell Int] 2026 Apr 08; Vol. 26 (1). Date of Electronic Publication: 2026 Apr 08.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101139795 Publication Model: Electronic Cited Medium: Print ISSN: 1475-2867 (Print) Linking ISSN: 14752867 NLM ISO Abbreviation: Cancer Cell Int Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1475-2867
DOI:10.1186/s12935-026-04297-0