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Methylome profiling reveals context-dependent chemo-resistance mechanisms and enhances risk stratification in AML.

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Title: Methylome profiling reveals context-dependent chemo-resistance mechanisms and enhances risk stratification in AML.
Authors: Chai Y; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore., Bono KAM; Centre for Translational Medicine, Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Tang NX; Centre for Translational Medicine, Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Ooi MG; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), The National University Health System (NUHS), 1E, Kent Ridge Road, Singapore, 119228, Singapore., Jen WY; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), The National University Health System (NUHS), 1E, Kent Ridge Road, Singapore, 119228, Singapore., Chan EHL; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), The National University Health System (NUHS), 1E, Kent Ridge Road, Singapore, 119228, Singapore., Lui PL; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), The National University Health System (NUHS), 1E, Kent Ridge Road, Singapore, 119228, Singapore., Ng CH; Centre for Clinical Hematology, Gleneagles Hospital, 6A Napier Road, Singapore, 258500, Singapore., Mohamed JS; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), The National University Health System (NUHS), 1E, Kent Ridge Road, Singapore, 119228, Singapore., Song F; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), The National University Health System (NUHS), 1E, Kent Ridge Road, Singapore, 119228, Singapore., White KP; Centre for Translational Medicine, Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; Department of Biochemistry and Precision Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore, 117596, Singapore., Chng WJ; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore. weejoo.chng@nus.edu.sg.; Centre for Translational Medicine, Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. weejoo.chng@nus.edu.sg.; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), The National University Health System (NUHS), 1E, Kent Ridge Road, Singapore, 119228, Singapore. weejoo.chng@nus.edu.sg.; NUS Centre for Cancer Research (N2CR), Centre for Translational Medicine, 14 Medical Drive, Singapore, 117599, Singapore. weejoo.chng@nus.edu.sg., Zhou J; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore. csizjb@nus.edu.sg.; Centre for Translational Medicine, Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. csizjb@nus.edu.sg.; NUS Centre for Cancer Research (N2CR), Centre for Translational Medicine, 14 Medical Drive, Singapore, 117599, Singapore. csizjb@nus.edu.sg.
Source: Cancer cell international [Cancer Cell Int] 2026 Apr 08; Vol. 26 (1). Date of Electronic Publication: 2026 Apr 08.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101139795 Publication Model: Electronic Cited Medium: Print ISSN: 1475-2867 (Print) Linking ISSN: 14752867 NLM ISO Abbreviation: Cancer Cell Int Subsets: PubMed not MEDLINE
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  Data: Methylome profiling reveals context-dependent chemo-resistance mechanisms and enhances risk stratification in AML.
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  Data: <searchLink fieldCode="AU" term="%22Chai+Y%22">Chai Y</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.<br /><searchLink fieldCode="AU" term="%22Bono+KAM%22">Bono KAM</searchLink>; Centre for Translational Medicine, Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.<br /><searchLink fieldCode="AU" term="%22Tang+NX%22">Tang NX</searchLink>; Centre for Translational Medicine, Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.<br /><searchLink fieldCode="AU" term="%22Ooi+MG%22">Ooi MG</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), The National University Health System (NUHS), 1E, Kent Ridge Road, Singapore, 119228, Singapore.<br /><searchLink fieldCode="AU" term="%22Jen+WY%22">Jen WY</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), The National University Health System (NUHS), 1E, Kent Ridge Road, Singapore, 119228, Singapore.<br /><searchLink fieldCode="AU" term="%22Chan+EHL%22">Chan EHL</searchLink>; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), The National University Health System (NUHS), 1E, Kent Ridge Road, Singapore, 119228, Singapore.<br /><searchLink fieldCode="AU" term="%22Lui+PL%22">Lui PL</searchLink>; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), The National University Health System (NUHS), 1E, Kent Ridge Road, Singapore, 119228, Singapore.<br /><searchLink fieldCode="AU" term="%22Ng+CH%22">Ng CH</searchLink>; Centre for Clinical Hematology, Gleneagles Hospital, 6A Napier Road, Singapore, 258500, Singapore.<br /><searchLink fieldCode="AU" term="%22Mohamed+JS%22">Mohamed JS</searchLink>; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), The National University Health System (NUHS), 1E, Kent Ridge Road, Singapore, 119228, Singapore.<br /><searchLink fieldCode="AU" term="%22Song+F%22">Song F</searchLink>; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), The National University Health System (NUHS), 1E, Kent Ridge Road, Singapore, 119228, Singapore.<br /><searchLink fieldCode="AU" term="%22White+KP%22">White KP</searchLink>; Centre for Translational Medicine, Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; Department of Biochemistry and Precision Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore, 117596, Singapore.<br /><searchLink fieldCode="AU" term="%22Chng+WJ%22">Chng WJ</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore. weejoo.chng@nus.edu.sg.; Centre for Translational Medicine, Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. weejoo.chng@nus.edu.sg.; Department of Hematology-Oncology, National University Cancer Institute of Singapore (NCIS), The National University Health System (NUHS), 1E, Kent Ridge Road, Singapore, 119228, Singapore. weejoo.chng@nus.edu.sg.; NUS Centre for Cancer Research (N2CR), Centre for Translational Medicine, 14 Medical Drive, Singapore, 117599, Singapore. weejoo.chng@nus.edu.sg.<br /><searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore. csizjb@nus.edu.sg.; Centre for Translational Medicine, Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. csizjb@nus.edu.sg.; NUS Centre for Cancer Research (N2CR), Centre for Translational Medicine, 14 Medical Drive, Singapore, 117599, Singapore. csizjb@nus.edu.sg.
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  Data: <searchLink fieldCode="JN" term="%22101139795%22">Cancer cell international</searchLink> [Cancer Cell Int] 2026 Apr 08; Vol. 26 (1). <i>Date of Electronic Publication: </i>2026 Apr 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101139795 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>1475-2867 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214752867%22">14752867 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Cell Int <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1186/s12935-026-04297-0
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        Text: English
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      – TitleFull: Methylome profiling reveals context-dependent chemo-resistance mechanisms and enhances risk stratification in AML.
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              Text: 2026 Apr 08
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