Double Mutations in Plasmodium falciparum Kelch13 drive resistance to next-generation artemisinin derivatives in malaria parasites.

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Bibliographic Details
Title: Double Mutations in Plasmodium falciparum Kelch13 drive resistance to next-generation artemisinin derivatives in malaria parasites.
Authors: Bower-Lepts C; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutic and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Aaron Diamond AIDS Research Center (ADARC), Columbia University Irving Medical Center, New York, NY, USA., Ward KE; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Wittlin S; Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; University of Basel, Basel, Switzerland., Stokes BH; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Yeo T; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Qahash T; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA., Small-Saunders JL; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutic and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Park H; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Uhlemann AC; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Llinás M; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA.; Huck Center for Malaria Research, Pennsylvania State University, University Park, PA, USA.; Department of Chemistry, Pennsylvania State University, University Park, PA, USA., Fidock DA; Center for Malaria Therapeutic and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Mok S; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutic and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Aaron Diamond AIDS Research Center (ADARC), Columbia University Irving Medical Center, New York, NY, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Apr 03. Date of Electronic Publication: 2026 Apr 03.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.64898/2026.04.02.716214