Shifts in protein aggregate stability define proteostasis decline in the aging human brain.

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Title: Shifts in protein aggregate stability define proteostasis decline in the aging human brain.
Authors: Anderton E; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA.; USC Leonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90191, USA., Burton JB; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA., King CD; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA., Foulger AC; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA., Bhaumik D; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA., Timonina D; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA., Mayeri Z; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA., Chamoli M; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA., Andersen JK; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA., Schilling B; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA., Lithgow GJ; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Apr 18. Date of Electronic Publication: 2026 Apr 18.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.64898/2026.03.27.714902