Targeting ST3GAL1 to downregulate ligands for the glycoimmune checkpoint Siglec-7 and reverse immune escape in hepatocellular carcinoma.
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| Title: | Targeting ST3GAL1 to downregulate ligands for the glycoimmune checkpoint Siglec-7 and reverse immune escape in hepatocellular carcinoma. |
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| Authors: | Fan TC; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan. b821615@life.nthu.edu.tw., Hung TH; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Yeh CT; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Liver Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Lin PT; Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Chang NC; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Lo TC; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Wu TJ; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Yu J; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Yu AL; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan. a1yu@health.ucsd.edu.; Genomics Research Center, Academia Sinica, Taipei, Taiwan. a1yu@health.ucsd.edu.; Department of Pediatrics/Hematology Oncology, University of California in San Diego, San Diego, CA, USA. a1yu@health.ucsd.edu. |
| Source: | Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2026 Apr 10; Vol. 75 (5). Date of Electronic Publication: 2026 Apr 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1432-0851 |
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| DOI: | 10.1007/s00262-026-04388-x |
