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Targeting ST3GAL1 to downregulate ligands for the glycoimmune checkpoint Siglec-7 and reverse immune escape in hepatocellular carcinoma.

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Title: Targeting ST3GAL1 to downregulate ligands for the glycoimmune checkpoint Siglec-7 and reverse immune escape in hepatocellular carcinoma.
Authors: Fan TC; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan. b821615@life.nthu.edu.tw., Hung TH; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Yeh CT; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Liver Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Lin PT; Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Chang NC; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Lo TC; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Wu TJ; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Yu J; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Yu AL; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan. a1yu@health.ucsd.edu.; Genomics Research Center, Academia Sinica, Taipei, Taiwan. a1yu@health.ucsd.edu.; Department of Pediatrics/Hematology Oncology, University of California in San Diego, San Diego, CA, USA. a1yu@health.ucsd.edu.
Source: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2026 Apr 10; Vol. 75 (5). Date of Electronic Publication: 2026 Apr 10.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting ST3GAL1 to downregulate ligands for the glycoimmune checkpoint Siglec-7 and reverse immune escape in hepatocellular carcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Fan+TC%22">Fan TC</searchLink>; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan. b821615@life.nthu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Hung+TH%22">Hung TH</searchLink>; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeh+CT%22">Yeh CT</searchLink>; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Liver Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+PT%22">Lin PT</searchLink>; Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+NC%22">Chang NC</searchLink>; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lo+TC%22">Lo TC</searchLink>; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+TJ%22">Wu TJ</searchLink>; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yu+J%22">Yu J</searchLink>; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yu+AL%22">Yu AL</searchLink>; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan. a1yu@health.ucsd.edu.; Genomics Research Center, Academia Sinica, Taipei, Taiwan. a1yu@health.ucsd.edu.; Department of Pediatrics/Hematology Oncology, University of California in San Diego, San Diego, CA, USA. a1yu@health.ucsd.edu.
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  Data: <searchLink fieldCode="JN" term="%228605732%22">Cancer immunology, immunotherapy : CII</searchLink> [Cancer Immunol Immunother] 2026 Apr 10; Vol. 75 (5). <i>Date of Electronic Publication: </i>2026 Apr 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>8605732 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0851 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203407004%22">03407004 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Immunol Immunother <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00262-026-04388-x
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      – Code: eng
        Text: English
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      – TitleFull: Targeting ST3GAL1 to downregulate ligands for the glycoimmune checkpoint Siglec-7 and reverse immune escape in hepatocellular carcinoma.
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              Text: 2026 Apr 10
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              Y: 2026
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