An Integrative Biophysical and Computational Workflow Uncovers New Allosteric Sites and Modulators of the Human A2A Adenosine Receptor.

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Bibliographic Details
Title: An Integrative Biophysical and Computational Workflow Uncovers New Allosteric Sites and Modulators of the Human A2A Adenosine Receptor.
Authors: Prudent R; Edelris, Bioparc, Bioserra 1 Building, 69008 Lyon, France., Ray AP; Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States., Thakur N; Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States., Moreno A; Eurofins Calixar, 60 Avenue Rockefeller, 69008 Lyon, France., Tandaric T; Department of Cell and Molecular Biology, Uppsala University, 751 24 Uppsala, Sweden.; Ruđer Bošković Institute, 10000 Zagreb, Croatia., Kanonenberg K; Eurofins Calixar, 60 Avenue Rockefeller, 69008 Lyon, France., Lemoine H; Edelris, Bioparc, Bioserra 1 Building, 69008 Lyon, France., Forcellini E; Edelris, Bioparc, Bioserra 1 Building, 69008 Lyon, France., Cecon E; Université Paris Cité, CNRS, Inserm, Institut Cochin, F-75014 Paris, France., Roche D; Edelris, Bioparc, Bioserra 1 Building, 69008 Lyon, France., Jockers R; Université Paris Cité, CNRS, Inserm, Institut Cochin, F-75014 Paris, France., Gutiérrez-de-Terán H; Department of Cell and Molecular Biology, Uppsala University, 751 24 Uppsala, Sweden.; Nanomaterials and Nanotechnology Research Center (CINN), Spanish National Research Council (CSIC), Health Research Institute of Asturias (ISPA), 33011 Oviedo, Asturias, Spain., Eddy MT; Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States.
Source: ACS chemical biology [ACS Chem Biol] 2026 May 15; Vol. 21 (5), pp. 1025-1037. Date of Electronic Publication: 2026 Apr 10.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1554-8937
DOI:10.1021/acschembio.6c00003