Bioengineered iPSC-derived human macrophages with increased angiotensin-converting enzyme (ACE) expression suppress solid tumor growth.
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| Title: | Bioengineered iPSC-derived human macrophages with increased angiotensin-converting enzyme (ACE) expression suppress solid tumor growth. |
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| Authors: | Shibata T; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Pharmacology, Yokohama City University School of Medicine, Yokohama, Japan., Bhat S; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, USA., Cao D; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Saito S; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Khan N; Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA, USA., Bernstein EA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Tokudome T; Department of Pharmacology, Yokohama City University School of Medicine, Yokohama, Japan., Okwan-Duodu D; Department of Pathology, Stanford University, Stanford, CA, USA., Tourtellotte WG; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Neurology and Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Bernstein KE; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Khan Z; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. zkhan@imbcr.org.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA. zkhan@imbcr.org.; The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. zkhan@imbcr.org.; Institute for Myeloma & Bone Cancer Research (IMBCR), West Hollywood, CA, USA. zkhan@imbcr.org. |
| Source: | Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Apr 13; Vol. 11 (1). Date of Electronic Publication: 2026 Apr 13. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2059-3635 |
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| DOI: | 10.1038/s41392-026-02650-3 |
