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Bioengineered iPSC-derived human macrophages with increased angiotensin-converting enzyme (ACE) expression suppress solid tumor growth.

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Title: Bioengineered iPSC-derived human macrophages with increased angiotensin-converting enzyme (ACE) expression suppress solid tumor growth.
Authors: Shibata T; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Pharmacology, Yokohama City University School of Medicine, Yokohama, Japan., Bhat S; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, USA., Cao D; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Saito S; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Khan N; Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA, USA., Bernstein EA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Tokudome T; Department of Pharmacology, Yokohama City University School of Medicine, Yokohama, Japan., Okwan-Duodu D; Department of Pathology, Stanford University, Stanford, CA, USA., Tourtellotte WG; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Neurology and Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Bernstein KE; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Khan Z; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. zkhan@imbcr.org.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA. zkhan@imbcr.org.; The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. zkhan@imbcr.org.; Institute for Myeloma & Bone Cancer Research (IMBCR), West Hollywood, CA, USA. zkhan@imbcr.org.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Apr 13; Vol. 11 (1). Date of Electronic Publication: 2026 Apr 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Bioengineered iPSC-derived human macrophages with increased angiotensin-converting enzyme (ACE) expression suppress solid tumor growth.
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  Data: <searchLink fieldCode="AU" term="%22Shibata+T%22">Shibata T</searchLink>; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Pharmacology, Yokohama City University School of Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Bhat+S%22">Bhat S</searchLink>; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cao+D%22">Cao D</searchLink>; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Saito+S%22">Saito S</searchLink>; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Khan+N%22">Khan N</searchLink>; Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bernstein+EA%22">Bernstein EA</searchLink>; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tokudome+T%22">Tokudome T</searchLink>; Department of Pharmacology, Yokohama City University School of Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Okwan-Duodu+D%22">Okwan-Duodu D</searchLink>; Department of Pathology, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tourtellotte+WG%22">Tourtellotte WG</searchLink>; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Neurology and Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bernstein+KE%22">Bernstein KE</searchLink>; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Khan+Z%22">Khan Z</searchLink>; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. zkhan@imbcr.org.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA. zkhan@imbcr.org.; The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. zkhan@imbcr.org.; Institute for Myeloma & Bone Cancer Research (IMBCR), West Hollywood, CA, USA. zkhan@imbcr.org.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101676423 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2059-3635 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220593635%22">20593635 </searchLink><i>NLM ISO Abbreviation: </i>Signal Transduct Target Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41392-026-02650-3
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              Text: 2026 Apr 13
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