Lidocaine for Depressive Symptoms and Comorbid Pain: A Narrative Review of Mechanisms, Evidence, and Safety.

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Title: Lidocaine for Depressive Symptoms and Comorbid Pain: A Narrative Review of Mechanisms, Evidence, and Safety.
Authors: Xia M; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China.; Department of Anesthesiology, General Hospital of the Yangtze River Shipping, Wuhan Brain Hospital, Wuhan, Hubei, People's Republic of China., Duan J; Liaoning Provincial Key Laboratory of Cerebral Diseases, Department of Physiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, People's Republic of China., Chen N; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China., Zhou W; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China., Zhang N; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China., Feng M; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China., Sun Y; Department of Anesthesiology, The General Hospital of Benxi Iron and Steel Group, Benxi, Liaoning, People's Republic of China., Luan Y; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China.
Source: Drug design, development and therapy [Drug Des Devel Ther] 2026 Apr 07; Vol. 20, pp. 580802. Date of Electronic Publication: 2026 Apr 07 (Print Publication: 2026).
Publication Type: Journal Article; Review
Journal Info: Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1177-8881
DOI:10.2147/DDDT.S580802