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Lidocaine for Depressive Symptoms and Comorbid Pain: A Narrative Review of Mechanisms, Evidence, and Safety.

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Title: Lidocaine for Depressive Symptoms and Comorbid Pain: A Narrative Review of Mechanisms, Evidence, and Safety.
Authors: Xia M; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China.; Department of Anesthesiology, General Hospital of the Yangtze River Shipping, Wuhan Brain Hospital, Wuhan, Hubei, People's Republic of China., Duan J; Liaoning Provincial Key Laboratory of Cerebral Diseases, Department of Physiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, People's Republic of China., Chen N; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China., Zhou W; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China., Zhang N; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China., Feng M; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China., Sun Y; Department of Anesthesiology, The General Hospital of Benxi Iron and Steel Group, Benxi, Liaoning, People's Republic of China., Luan Y; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China.
Source: Drug design, development and therapy [Drug Des Devel Ther] 2026 Apr 07; Vol. 20, pp. 580802. Date of Electronic Publication: 2026 Apr 07 (Print Publication: 2026).
Publication Type: Journal Article; Review
Journal Info: Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Lidocaine for Depressive Symptoms and Comorbid Pain: A Narrative Review of Mechanisms, Evidence, and Safety.
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  Data: <searchLink fieldCode="AU" term="%22Xia+M%22">Xia M</searchLink>; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China.; Department of Anesthesiology, General Hospital of the Yangtze River Shipping, Wuhan Brain Hospital, Wuhan, Hubei, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Duan+J%22">Duan J</searchLink>; Liaoning Provincial Key Laboratory of Cerebral Diseases, Department of Physiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Chen+N%22">Chen N</searchLink>; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhou+W%22">Zhou W</searchLink>; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhang+N%22">Zhang N</searchLink>; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Feng+M%22">Feng M</searchLink>; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Department of Anesthesiology, The General Hospital of Benxi Iron and Steel Group, Benxi, Liaoning, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Luan+Y%22">Luan Y</searchLink>; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Dove+Press+Limited%22">Dove Press Limited </searchLink><i>Country of Publication: </i>New Zealand <i>NLM ID: </i>101475745 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1177-8881 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2211778881%22">11778881 </searchLink><i>NLM ISO Abbreviation: </i>Drug Des Devel Ther <i>Subsets: </i>MEDLINE
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        Value: 10.2147/DDDT.S580802
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      – Code: eng
        Text: English
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        StartPage: 580802
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      – TitleFull: Lidocaine for Depressive Symptoms and Comorbid Pain: A Narrative Review of Mechanisms, Evidence, and Safety.
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            NameFull: Xia M
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            NameFull: Chen N
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            – D: 07
              M: 04
              Text: 2026 Apr 07
              Type: published
              Y: 2026
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              Value: 20
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