Hybrid benzylidene thiazolidine-2,4-diones as potent apoptosis-inducing anticancer agents: design-driven optimization, cytotoxic profiling, and mechanistic validation in prostate cancer.

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Title: Hybrid benzylidene thiazolidine-2,4-diones as potent apoptosis-inducing anticancer agents: design-driven optimization, cytotoxic profiling, and mechanistic validation in prostate cancer.
Authors: Shaaban S; Department of Chemistry, College of Science, King Faisal University Al-Ahsa 31982 Saudi Arabia sibrahim@kfu.edu.sa., Hawas SS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt New Damietta 34518 Egypt akarmalawy@horus.edu.eg., Sharaky M; Cancer Biology Department, Pharmacology Unit, National Cancer Institute (NCI), Cairo University Cairo Egypt., Ba-Ghazal H; Department of Chemistry, College of Science, King Faisal University Al-Ahsa 31982 Saudi Arabia sibrahim@kfu.edu.sa., Elmaaty AA; Medicinal Chemistry Department, Faculty of Pharmacy, Port Said University Port Said 42526 Egypt.; Medicinal Chemistry Department, Clinical Pharmacy Program, East Port Said National University Port Said 42526 Egypt., Alomari KB; Jazan University, Department of Physical Sciences, Chemistry Division 45142 Jazan Kingdom of Saudi Arabia., Alaasar M; Department of Chemistry, Faculty of Science, Cairo University Giza Egypt., Elsharif AM; Department of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University Dammam 31441 Saudi Arabia., Alatawi FS; Department of Biochemistry, Faculty of Science, University of Tabuk Tabuk Saudi Arabia., Mohamed MA; Department of Chemistry, Faculty of Science, Mansoura University Mansoura Egypt., Al Khatib AO; Faculty of Pharmacy, Al-Ahliyya Amman University Amman Jordan., Al-Karmalawy AA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt New Damietta 34518 Egypt akarmalawy@horus.edu.eg.; Department of Pharmaceutical Chemistry, College of Pharmacy, The University of Mashreq Baghdad 10023 Iraq.
Source: RSC advances [RSC Adv] 2026 Apr 12; Vol. 16 (21), pp. 19144-19157. Date of Electronic Publication: 2026 Apr 12 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101581657 Publication Model: eCollection Cited Medium: Internet ISSN: 2046-2069 (Electronic) Linking ISSN: 20462069 NLM ISO Abbreviation: RSC Adv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2046-2069
DOI:10.1039/d6ra01323f