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High glucose impairs cognitive function through Creb3 O-GlcNAcylation and increased lactate production.

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Title: High glucose impairs cognitive function through Creb3 O-GlcNAcylation and increased lactate production.
Authors: Xu J; Department of Endocrinology and Metabolism, Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541199, P. R. China.; Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi 541199, P. R. China.; Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, Guangxi 541199, P. R. China., Yang X; Department of Endocrinology and Metabolism, Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541199, P. R. China.; Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi 541199, P. R. China., Cao J; Department of Endocrinology and Metabolism, Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541199, P. R. China.; Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi 541199, P. R. China., Hao Y; Department of Endocrinology and Metabolism, Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541199, P. R. China.; Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi 541199, P. R. China., Nie R; Department of Integrated Traditional Chinese and Western Medicine, First Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541001, P. R. China., Zhong Q; Department of Endocrinology and Metabolism, Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541199, P. R. China.; Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, Guangxi 541199, P. R. China., Gao Y; Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P. R. China., Hui Y; Department of Endocrinology and Metabolism, Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541199, P. R. China.; Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi 541199, P. R. China.; Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, Guangxi 541199, P. R. China., Kuang L; Department of Endocrinology and Metabolism, Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541199, P. R. China.; Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi 541199, P. R. China., Zhong Y; Department of Endocrinology and Metabolism, Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541199, P. R. China.; Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, Guangxi 541199, P. R. China., Mo B; Guangxi Clinical Research Center for Diabetes and Metabolic Diseases, Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541199, P. R. China., Zeng X; Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi 541199, P. R. China., Zheng T; Department of Endocrinology and Metabolism, Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541199, P. R. China.; Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi 541199, P. R. China.; Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, Guangxi 541199, P. R. China.
Source: Science signaling [Sci Signal] 2026 Apr 14; Vol. 19 (933), pp. eadx4313. Date of Electronic Publication: 2026 Apr 14.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1937-9145
DOI:10.1126/scisignal.adx4313