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AI-assisted transformation of PD-L1 inhibitory peptides into small molecules using amino acid mapping descriptor and activity improvement through structure-based drug design.

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Bibliographic Details
Title: AI-assisted transformation of PD-L1 inhibitory peptides into small molecules using amino acid mapping descriptor and activity improvement through structure-based drug design.
Authors: Ohira S; Analysis Technology Center, FUJIFILM Corporation, 210, Nakamuma, Minamiashigara-shi, Kanagawa 250-0193, Japan., Doi I; Analysis Technology Center, FUJIFILM Corporation, 210, Nakamuma, Minamiashigara-shi, Kanagawa 250-0193, Japan., Nakabayashi J; Analysis Technology Center, FUJIFILM Corporation, 210, Nakamuma, Minamiashigara-shi, Kanagawa 250-0193, Japan., Tanaka H; CRO Business Development Office, FUJIFILM Corporation, 7-3, Akasaka 9-Chome, Minato-ku, Tokyo 107-0052, Japan., Sonoda Y; Analysis Technology Center, FUJIFILM Corporation, 210, Nakamuma, Minamiashigara-shi, Kanagawa 250-0193, Japan., Ammar YB; Analysis Technology Center, FUJIFILM Corporation, 210, Nakamuma, Minamiashigara-shi, Kanagawa 250-0193, Japan., Kochi M; Analysis Technology Center, FUJIFILM Corporation, 210, Nakamuma, Minamiashigara-shi, Kanagawa 250-0193, Japan., Tanaka T; CRO Business Development Office, FUJIFILM Corporation, 7-3, Akasaka 9-Chome, Minato-ku, Tokyo 107-0052, Japan., Tsumura K; Analysis Technology Center, FUJIFILM Corporation, 210, Nakamuma, Minamiashigara-shi, Kanagawa 250-0193, Japan. Electronic address: kyosuke.tsumura@fujifilm.com.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2026 Aug; Vol. 137, pp. 130655. Date of Electronic Publication: 2026 Apr 13.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1464-3405
DOI:10.1016/j.bmcl.2026.130655