Tumor-derived branched-chain α-keto acids activate Notch signaling in tumor-associated macrophages to limit immunity.

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Title: Tumor-derived branched-chain α-keto acids activate Notch signaling in tumor-associated macrophages to limit immunity.
Authors: Ma QX; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences and School of Basic Medical Sciences; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; Shanghai Key Laboratory of Radiation Oncology; Shanghai Key Laboratory of Medical Epigenetics; National Key Laboratory of Brain Function and Diseases; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Zhao R; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences and School of Basic Medical Sciences; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; Shanghai Key Laboratory of Radiation Oncology; Shanghai Key Laboratory of Medical Epigenetics; National Key Laboratory of Brain Function and Diseases; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Han JX; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences and School of Basic Medical Sciences; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; Shanghai Key Laboratory of Radiation Oncology; Shanghai Key Laboratory of Medical Epigenetics; National Key Laboratory of Brain Function and Diseases; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Zhu WY; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences and School of Basic Medical Sciences; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; Shanghai Key Laboratory of Radiation Oncology; Shanghai Key Laboratory of Medical Epigenetics; National Key Laboratory of Brain Function and Diseases; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Xu MD; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.; Institute of Pathology, Fudan University, Shanghai, China., Zhang XY; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.; Institute of Pathology, Fudan University, Shanghai, China., Yan GQ; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences and School of Basic Medical Sciences; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; Shanghai Key Laboratory of Radiation Oncology; Shanghai Key Laboratory of Medical Epigenetics; National Key Laboratory of Brain Function and Diseases; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Wen WY; Department of Neurosurgery; Huashan Hospital; the Shanghai Key Laboratory of Medical Epigenetics; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science; Institutes of Biomedical Sciences; School of Basic Medical Sciences, Fudan University, Shanghai, China., Han GC; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences and School of Basic Medical Sciences; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; Shanghai Key Laboratory of Radiation Oncology; Shanghai Key Laboratory of Medical Epigenetics; National Key Laboratory of Brain Function and Diseases; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Luo M; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences and School of Basic Medical Sciences; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; Shanghai Key Laboratory of Radiation Oncology; Shanghai Key Laboratory of Medical Epigenetics; National Key Laboratory of Brain Function and Diseases; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Yin M; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences and School of Basic Medical Sciences; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; Shanghai Key Laboratory of Radiation Oncology; Shanghai Key Laboratory of Medical Epigenetics; National Key Laboratory of Brain Function and Diseases; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. miaoyin@fudan.edu.cn., Li JT; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences and School of Basic Medical Sciences; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; Shanghai Key Laboratory of Radiation Oncology; Shanghai Key Laboratory of Medical Epigenetics; National Key Laboratory of Brain Function and Diseases; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. lijt15@fudan.edu.cn., Lei QY; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences and School of Basic Medical Sciences; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; Shanghai Key Laboratory of Radiation Oncology; Shanghai Key Laboratory of Medical Epigenetics; National Key Laboratory of Brain Function and Diseases; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. qlei@fudan.edu.cn.; New Cornerstone Science Laboratory, School of Basic Medical Sciences, Fudan University, Shanghai, China. qlei@fudan.edu.cn.
Source: Nature immunology [Nat Immunol] 2026 Jun; Vol. 27 (6), pp. 1169-1183. Date of Electronic Publication: 2026 Apr 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1529-2916
DOI:10.1038/s41590-026-02484-9