Engineering a robust IsPETase for energy-efficient PET depolymerization in natural seawater at ambient temperatures.

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Title: Engineering a robust IsPETase for energy-efficient PET depolymerization in natural seawater at ambient temperatures.
Authors: Huang X; State Key Laboratory of Biocontrol, Innovation Center for Evolutionary Synthetic Biology, Guangzhou Innovation Center of Biotechnology and Biomanufacturing, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, China., Jia Q; State Key Laboratory of Biocontrol, Innovation Center for Evolutionary Synthetic Biology, Guangzhou Innovation Center of Biotechnology and Biomanufacturing, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, China., Li G; State Key Laboratory of Biocontrol, Innovation Center for Evolutionary Synthetic Biology, Guangzhou Innovation Center of Biotechnology and Biomanufacturing, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, China., Yang X; State Key Laboratory of Biocontrol, Innovation Center for Evolutionary Synthetic Biology, Guangzhou Innovation Center of Biotechnology and Biomanufacturing, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, China., Xu S; State Key Laboratory of Biocontrol, Innovation Center for Evolutionary Synthetic Biology, Guangzhou Innovation Center of Biotechnology and Biomanufacturing, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, China., Liu J; State Key Laboratory of Biocontrol, Innovation Center for Evolutionary Synthetic Biology, Guangzhou Innovation Center of Biotechnology and Biomanufacturing, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, China., Li W; State Key Laboratory of Biocontrol, Innovation Center for Evolutionary Synthetic Biology, Guangzhou Innovation Center of Biotechnology and Biomanufacturing, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, China., Liu Y; State Key Laboratory of Biocontrol, Innovation Center for Evolutionary Synthetic Biology, Guangzhou Innovation Center of Biotechnology and Biomanufacturing, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, China., Xie W; State Key Laboratory of Biocontrol, Innovation Center for Evolutionary Synthetic Biology, Guangzhou Innovation Center of Biotechnology and Biomanufacturing, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, China. xiewei6@mail.sysu.edu.cn., Cao L; State Key Laboratory of Biocontrol, Innovation Center for Evolutionary Synthetic Biology, Guangzhou Innovation Center of Biotechnology and Biomanufacturing, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, China. caolch5@mail.sysu.edu.cn.
Source: Advanced biotechnology [Adv Biotechnol (Singap)] 2026 Apr 15; Vol. 4 (2). Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Singapore Country of Publication: Singapore NLM ID: 9918821788106676 Publication Model: Electronic Cited Medium: Internet ISSN: 2948-2801 (Electronic) Linking ISSN: 29482801 NLM ISO Abbreviation: Adv Biotechnol (Singap) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:2948-2801
DOI:10.1007/s44307-026-00104-z