Intrawound Tobramycin Plus Vancomycin to Prevent Surgical Site Infection in Tibial Fractures: The TOBRA Randomized Clinical Trial.
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| Title: | Intrawound Tobramycin Plus Vancomycin to Prevent Surgical Site Infection in Tibial Fractures: The TOBRA Randomized Clinical Trial. |
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| Authors: | O'Toole RV; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., O'Hara NN; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Carlini AR; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Schrank GM; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Chung S; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Gary JL; University of Southern California Keck School of Medicine, Los Angeles., Obremskey W; Vanderbilt University Medical Center, Nashville, Tennessee., Matuszewski PE; University of Kentucky, Lexington., Teague D; University of Oklahoma Medical Center, Oklahoma City., Natoli RM; Indiana University Health Methodist Hospital, Indianapolis., Gitajn IL; Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire., Weaver MJ; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Renninger CH; Walter Reed National Military Medical Center, Bethesda, Maryland., Levack AE; Loyola University Medical Center, Maywood, Illinois., Degani Y; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Collins SC; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Weston-Farber E; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Howe AL; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Thompson RE; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Castillo RC; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Karunakar MA; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Blum L; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Harmer L; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Hsu JR; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Kempton LB; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Phelps KD; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Seymour RB; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Sims SH; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Acharya MS; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Callahan H; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Chavez-Araujo LM; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Churchill C; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Gambuzza MP; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Haim KR; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Ishman E; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Kendall JS; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina.; Now with Loma Linda School of Medicine, Loma Linda, California., Mullis ND; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Young C; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Pilson HT; Atrium Health-Wake Forest Baptist, Winston-Salem, North Carolina., Carroll EA; Atrium Health-Wake Forest Baptist, Winston-Salem, North Carolina., Goodman JB; Atrium Health-Wake Forest Baptist, Winston-Salem, North Carolina., Holden MB; Atrium Health-Wake Forest Baptist, Winston-Salem, North Carolina., Jones AL; Baylor Scott & White Health, Dallas, Texas., Moon C; Cedars-Sinai Medical Center, Los Angeles, California., Lin CA; Cedars-Sinai Medical Center, Los Angeles, California., Marecek GS; Cedars-Sinai Medical Center, Los Angeles, California., Moffitt GB; Corewell Health, Grand Rapids, Michigan., Conlan T; Corewell Health, Grand Rapids, Michigan., George AV; Corewell Health, Grand Rapids, Michigan., Fisher LA; Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire., Mullin DS; Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire., Recendez CL; Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire., Aneja A; Harvard University, Boston, Massachusetts., Brameier DT; Harvard University, Boston, Massachusetts., Heng M; Harvard University, Boston, Massachusetts.; Now with Boston Medical Center-Brighton., Ly TV; Harvard University, Boston, Massachusetts., Stenquist DS; Harvard University, Boston, Massachusetts., Suneja N; Harvard University, Boston, Massachusetts., Wignakumar T; Harvard University, Boston, Massachusetts., Borgida JS; Harvard University, Boston, Massachusetts., Policicchio TJ; Harvard University, Boston, Massachusetts., Hanson GR; Hennepin Healthcare, Minneapolis, Minnesota., Alese OM; Hennepin Healthcare, Minneapolis, Minnesota., Ricci WM; Hospital of Special Surgery & NewYork-Presbyterian Hospital, New York., Behrens SB; Hospital of Special Surgery & NewYork-Presbyterian Hospital, New York., Dvorzhinskiy A; Hospital of Special Surgery & NewYork-Presbyterian Hospital, New York., Bilodeau RE; Hospital of Special Surgery & NewYork-Presbyterian Hospital, New York., Klinger CE; Hospital of Special Surgery & NewYork-Presbyterian Hospital, New York., Mullis BH; Indiana University Health Methodist Hospital, Indianapolis., Jang Y; Indiana University Health Methodist Hospital, Indianapolis., Lopas LA; Indiana University Health Methodist Hospital, Indianapolis., McKinley TO; Indiana University Health Methodist Hospital, Indianapolis., O'Neill DC; Indiana University Health Methodist Hospital, Indianapolis., Szatkowski JP; Indiana University Health Methodist Hospital, Indianapolis., Virkus WW; Indiana University Health Methodist Hospital, Indianapolis., Hill LC; Indiana University Health Methodist Hospital, Indianapolis., Gaski G; Inova Fairfax Medical Campus, Fairfax, Virginia., Hymes RA; Inova Fairfax Medical Campus, Fairfax, Virginia., Ahn J; Inova Fairfax Medical Campus, Fairfax, Virginia., Goch AM; Inova Fairfax Medical Campus, Fairfax, Virginia., Holzman M; Inova Fairfax Medical Campus, Fairfax, Virginia., Malekzadeh AS; Inova Fairfax Medical Campus, Fairfax, Virginia., Schulman JE; Inova Fairfax Medical Campus, Fairfax, Virginia., Rivera JC; Louisiana State University, New Orleans., Krause PC; Louisiana State University, New Orleans., Bridgman C; Louisiana State University, New Orleans., Cohen J; Loyola University Medical Center, Maywood, Illinois., Eikani C; Loyola University Medical Center, Maywood, Illinois., Chavez M; Loyola University Medical Center, Maywood, Illinois., Kudulis M; Loyola University Medical Center, Maywood, Illinois., Warner SJ; McGovern Medical School at the University of Texas Health Science Center at Houston., Achor TS; McGovern Medical School at the University of Texas Health Science Center at Houston., Choo A; McGovern Medical School at the University of Texas Health Science Center at Houston., Eastman JG; McGovern Medical School at the University of Texas Health Science Center at Houston., Kellam PJ; McGovern Medical School at the University of Texas Health Science Center at Houston., Boutte SJ; McGovern Medical School at the University of Texas Health Science Center at Houston., Guevara KD; McGovern Medical School at the University of Texas Health Science Center at Houston., Reid KR; Medical University of South Carolina, Charleston., Vallier HA; MetroHealth Medical Center, Cleveland, Ohio., Tucci AV; MetroHealth Medical Center, Cleveland, Ohio., Davis JM; Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania., Bell AC; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Bonyun ME; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Healey K; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Li V; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.; Now with University of Texas Southwestern, Dallas., McKibben NS; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.; Now with Oregon Health & Science University, Portland., Nascone J; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Okhuereigbe D; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Sciadini MF; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Slobogean G; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.; Now with University of California, Irvine., Zingas N; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Kovvur M; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.; Now with University of Pittsburgh, Pennsylvania., Lawrence JE; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.; Now with MedStar Health, Washington, DC., Phipps H; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Rudnicki J; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.; Now with Johns Hopkins Hospital, Baltimore, Maryland., Turner KE; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.; Now with Georgetown University, Washington, DC., Hayda R; Rhode Island Hospital at Brown University, Providence., Evans AR; Rhode Island Hospital at Brown University, Providence., Quinnan S; St Mary's Medical Center, West Palm Beach, Florida., Benitez A; St Mary's Medical Center, West Palm Beach, Florida., Rehman S; Temple University Hospital, Philadelphia, Pennsylvania., Soderquist MC; Temple University Hospital, Philadelphia, Pennsylvania.; Now with Robert Wood Johnson Barnabas Health, Jersey City, New Jersey., Townsend CB; Temple University Hospital, Philadelphia, Pennsylvania., Caroom C; Texas Tech University Health Sciences Center, Lubbock., Collins AC; Ohio State University Medical Center, Columbus., Okwumabua E; Ohio State University Medical Center, Columbus., Shaikh HS; Ohio State University Medical Center, Columbus., Spitler CA; University of Alabama at Birmingham., Agarwal A; University of Alabama at Birmingham., Johnson MD; University of Alabama at Birmingham., Haller JM; University of Utah, Salt Lake City., Marchand LS; University of Utah, Salt Lake City., Alfonso NA; University of Colorado Medicine, Aurora., Gorman MA; University of Colorado Medicine, Aurora., Charlton WM; University of Kentucky, Lexington., Scott BR; University of Kentucky, Lexington., Kraus KM; University of Kentucky, Lexington., Meredith SJ; University of Maryland Capital Region Health, Largo., Talwar S; University of Maryland Capital Region Health, Largo., Bergin PF; University of Mississippi Medical Center, Jackson., Jha AJ; University of Mississippi Medical Center, Jackson.; Now with Maimonides Medical Center, Brooklyn, New York., McGee S; University of Mississippi Medical Center, Jackson., Nehete PV; University of Mississippi Medical Center, Jackson., Pryor TA; University of Mississippi Medical Center, Jackson., Spears I; University of Mississippi Medical Center, Jackson., Chen AT; University of North Carolina School of Medicine, Chapel Hill., Kelley B; University of North Carolina School of Medicine, Chapel Hill., Nez NR; University of North Carolina School of Medicine, Chapel Hill., Ertl WJ; University of Oklahoma Medical Center, Oklahoma City., Hull BR; University of Oklahoma Medical Center, Oklahoma City., Blumenthal S; University of Southern California Keck School of Medicine, Los Angeles., Patterson JT; University of Southern California Keck School of Medicine, Los Angeles., Flynn C; University of Southern California Keck School of Medicine, Los Angeles., Ross RC; University of Southern California Keck School of Medicine, Los Angeles., Agarwal A; University of Texas Health Sciences Center, San Antonio., Weiss DB; University of Virginia Medical Center, Charlottesville., Hadeed MM; University of Virginia Medical Center, Charlottesville., Yarboro SR; University of Virginia Medical Center, Charlottesville., Daoud T; University of Virginia Medical Center, Charlottesville., McVey ED; University of Virginia Medical Center, Charlottesville., Whiting PS; University of Wisconsin, Madison., Domes C; University of Wisconsin, Madison., Goodspeed DC; University of Wisconsin, Madison., Kuhn GR; University of Wisconsin, Madison., Boyce R; Vanderbilt University Medical Center, Nashville, Tennessee., Libos A; Vanderbilt University Medical Center, Nashville, Tennessee.; Now with Fundacion Santa Fe de Bogota, Colombia., Mitchell PM; Vanderbilt University Medical Center, Nashville, Tennessee., Moreno-Diaz AF; Vanderbilt University Medical Center, Nashville, Tennessee., Ponce RB; Vanderbilt University Medical Center, Nashville, Tennessee.; Now with Wright State University Boonshoft School of Medicine, Dayton, Ohio., Stinner DJ; Vanderbilt University Medical Center, Nashville, Tennessee., Tatman LM; Vanderbilt University Medical Center, Nashville, Tennessee., Velasco-Castro J; Vanderbilt University Medical Center, Nashville, Tennessee., Trochez K; Vanderbilt University Medical Center, Nashville, Tennessee., Satpathy J; Virginia Commonwealth University, Richmond., Zuelzer DA; Virginia Commonwealth University, Richmond., Potter BK; Walter Reed National Military Medical Center, Bethesda, Maryland.; Now with the University of Pennsylvania, Philadelphia. |
| Corporate Authors: | Major Extremity Trauma Research Consortium (METRC) |
| Source: | JAMA [JAMA] 2026 May 12; Vol. 335 (18), pp. 1586-1595. |
| Publication Type: | Clinical Trial, Phase III; Comparative Study; Equivalence Trial; Journal Article; Multicenter Study; Randomized Controlled Trial |
| Journal Info: | Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1538-3598 |
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| DOI: | 10.1001/jama.2026.4023 |
