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Intrawound Tobramycin Plus Vancomycin to Prevent Surgical Site Infection in Tibial Fractures: The TOBRA Randomized Clinical Trial.

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Title: Intrawound Tobramycin Plus Vancomycin to Prevent Surgical Site Infection in Tibial Fractures: The TOBRA Randomized Clinical Trial.
Authors: O'Toole RV; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., O'Hara NN; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Carlini AR; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Schrank GM; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Chung S; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Gary JL; University of Southern California Keck School of Medicine, Los Angeles., Obremskey W; Vanderbilt University Medical Center, Nashville, Tennessee., Matuszewski PE; University of Kentucky, Lexington., Teague D; University of Oklahoma Medical Center, Oklahoma City., Natoli RM; Indiana University Health Methodist Hospital, Indianapolis., Gitajn IL; Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire., Weaver MJ; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Renninger CH; Walter Reed National Military Medical Center, Bethesda, Maryland., Levack AE; Loyola University Medical Center, Maywood, Illinois., Degani Y; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Collins SC; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Weston-Farber E; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Howe AL; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Thompson RE; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Castillo RC; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Karunakar MA; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Blum L; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Harmer L; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Hsu JR; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Kempton LB; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Phelps KD; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Seymour RB; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Sims SH; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Acharya MS; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Callahan H; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Chavez-Araujo LM; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Churchill C; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Gambuzza MP; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Haim KR; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Ishman E; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Kendall JS; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina.; Now with Loma Linda School of Medicine, Loma Linda, California., Mullis ND; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Young C; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina., Pilson HT; Atrium Health-Wake Forest Baptist, Winston-Salem, North Carolina., Carroll EA; Atrium Health-Wake Forest Baptist, Winston-Salem, North Carolina., Goodman JB; Atrium Health-Wake Forest Baptist, Winston-Salem, North Carolina., Holden MB; Atrium Health-Wake Forest Baptist, Winston-Salem, North Carolina., Jones AL; Baylor Scott & White Health, Dallas, Texas., Moon C; Cedars-Sinai Medical Center, Los Angeles, California., Lin CA; Cedars-Sinai Medical Center, Los Angeles, California., Marecek GS; Cedars-Sinai Medical Center, Los Angeles, California., Moffitt GB; Corewell Health, Grand Rapids, Michigan., Conlan T; Corewell Health, Grand Rapids, Michigan., George AV; Corewell Health, Grand Rapids, Michigan., Fisher LA; Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire., Mullin DS; Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire., Recendez CL; Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire., Aneja A; Harvard University, Boston, Massachusetts., Brameier DT; Harvard University, Boston, Massachusetts., Heng M; Harvard University, Boston, Massachusetts.; Now with Boston Medical Center-Brighton., Ly TV; Harvard University, Boston, Massachusetts., Stenquist DS; Harvard University, Boston, Massachusetts., Suneja N; Harvard University, Boston, Massachusetts., Wignakumar T; Harvard University, Boston, Massachusetts., Borgida JS; Harvard University, Boston, Massachusetts., Policicchio TJ; Harvard University, Boston, Massachusetts., Hanson GR; Hennepin Healthcare, Minneapolis, Minnesota., Alese OM; Hennepin Healthcare, Minneapolis, Minnesota., Ricci WM; Hospital of Special Surgery & NewYork-Presbyterian Hospital, New York., Behrens SB; Hospital of Special Surgery & NewYork-Presbyterian Hospital, New York., Dvorzhinskiy A; Hospital of Special Surgery & NewYork-Presbyterian Hospital, New York., Bilodeau RE; Hospital of Special Surgery & NewYork-Presbyterian Hospital, New York., Klinger CE; Hospital of Special Surgery & NewYork-Presbyterian Hospital, New York., Mullis BH; Indiana University Health Methodist Hospital, Indianapolis., Jang Y; Indiana University Health Methodist Hospital, Indianapolis., Lopas LA; Indiana University Health Methodist Hospital, Indianapolis., McKinley TO; Indiana University Health Methodist Hospital, Indianapolis., O'Neill DC; Indiana University Health Methodist Hospital, Indianapolis., Szatkowski JP; Indiana University Health Methodist Hospital, Indianapolis., Virkus WW; Indiana University Health Methodist Hospital, Indianapolis., Hill LC; Indiana University Health Methodist Hospital, Indianapolis., Gaski G; Inova Fairfax Medical Campus, Fairfax, Virginia., Hymes RA; Inova Fairfax Medical Campus, Fairfax, Virginia., Ahn J; Inova Fairfax Medical Campus, Fairfax, Virginia., Goch AM; Inova Fairfax Medical Campus, Fairfax, Virginia., Holzman M; Inova Fairfax Medical Campus, Fairfax, Virginia., Malekzadeh AS; Inova Fairfax Medical Campus, Fairfax, Virginia., Schulman JE; Inova Fairfax Medical Campus, Fairfax, Virginia., Rivera JC; Louisiana State University, New Orleans., Krause PC; Louisiana State University, New Orleans., Bridgman C; Louisiana State University, New Orleans., Cohen J; Loyola University Medical Center, Maywood, Illinois., Eikani C; Loyola University Medical Center, Maywood, Illinois., Chavez M; Loyola University Medical Center, Maywood, Illinois., Kudulis M; Loyola University Medical Center, Maywood, Illinois., Warner SJ; McGovern Medical School at the University of Texas Health Science Center at Houston., Achor TS; McGovern Medical School at the University of Texas Health Science Center at Houston., Choo A; McGovern Medical School at the University of Texas Health Science Center at Houston., Eastman JG; McGovern Medical School at the University of Texas Health Science Center at Houston., Kellam PJ; McGovern Medical School at the University of Texas Health Science Center at Houston., Boutte SJ; McGovern Medical School at the University of Texas Health Science Center at Houston., Guevara KD; McGovern Medical School at the University of Texas Health Science Center at Houston., Reid KR; Medical University of South Carolina, Charleston., Vallier HA; MetroHealth Medical Center, Cleveland, Ohio., Tucci AV; MetroHealth Medical Center, Cleveland, Ohio., Davis JM; Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania., Bell AC; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Bonyun ME; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Healey K; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Li V; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.; Now with University of Texas Southwestern, Dallas., McKibben NS; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.; Now with Oregon Health & Science University, Portland., Nascone J; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Okhuereigbe D; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Sciadini MF; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Slobogean G; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.; Now with University of California, Irvine., Zingas N; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Kovvur M; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.; Now with University of Pittsburgh, Pennsylvania., Lawrence JE; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.; Now with MedStar Health, Washington, DC., Phipps H; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore., Rudnicki J; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.; Now with Johns Hopkins Hospital, Baltimore, Maryland., Turner KE; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.; Now with Georgetown University, Washington, DC., Hayda R; Rhode Island Hospital at Brown University, Providence., Evans AR; Rhode Island Hospital at Brown University, Providence., Quinnan S; St Mary's Medical Center, West Palm Beach, Florida., Benitez A; St Mary's Medical Center, West Palm Beach, Florida., Rehman S; Temple University Hospital, Philadelphia, Pennsylvania., Soderquist MC; Temple University Hospital, Philadelphia, Pennsylvania.; Now with Robert Wood Johnson Barnabas Health, Jersey City, New Jersey., Townsend CB; Temple University Hospital, Philadelphia, Pennsylvania., Caroom C; Texas Tech University Health Sciences Center, Lubbock., Collins AC; Ohio State University Medical Center, Columbus., Okwumabua E; Ohio State University Medical Center, Columbus., Shaikh HS; Ohio State University Medical Center, Columbus., Spitler CA; University of Alabama at Birmingham., Agarwal A; University of Alabama at Birmingham., Johnson MD; University of Alabama at Birmingham., Haller JM; University of Utah, Salt Lake City., Marchand LS; University of Utah, Salt Lake City., Alfonso NA; University of Colorado Medicine, Aurora., Gorman MA; University of Colorado Medicine, Aurora., Charlton WM; University of Kentucky, Lexington., Scott BR; University of Kentucky, Lexington., Kraus KM; University of Kentucky, Lexington., Meredith SJ; University of Maryland Capital Region Health, Largo., Talwar S; University of Maryland Capital Region Health, Largo., Bergin PF; University of Mississippi Medical Center, Jackson., Jha AJ; University of Mississippi Medical Center, Jackson.; Now with Maimonides Medical Center, Brooklyn, New York., McGee S; University of Mississippi Medical Center, Jackson., Nehete PV; University of Mississippi Medical Center, Jackson., Pryor TA; University of Mississippi Medical Center, Jackson., Spears I; University of Mississippi Medical Center, Jackson., Chen AT; University of North Carolina School of Medicine, Chapel Hill., Kelley B; University of North Carolina School of Medicine, Chapel Hill., Nez NR; University of North Carolina School of Medicine, Chapel Hill., Ertl WJ; University of Oklahoma Medical Center, Oklahoma City., Hull BR; University of Oklahoma Medical Center, Oklahoma City., Blumenthal S; University of Southern California Keck School of Medicine, Los Angeles., Patterson JT; University of Southern California Keck School of Medicine, Los Angeles., Flynn C; University of Southern California Keck School of Medicine, Los Angeles., Ross RC; University of Southern California Keck School of Medicine, Los Angeles., Agarwal A; University of Texas Health Sciences Center, San Antonio., Weiss DB; University of Virginia Medical Center, Charlottesville., Hadeed MM; University of Virginia Medical Center, Charlottesville., Yarboro SR; University of Virginia Medical Center, Charlottesville., Daoud T; University of Virginia Medical Center, Charlottesville., McVey ED; University of Virginia Medical Center, Charlottesville., Whiting PS; University of Wisconsin, Madison., Domes C; University of Wisconsin, Madison., Goodspeed DC; University of Wisconsin, Madison., Kuhn GR; University of Wisconsin, Madison., Boyce R; Vanderbilt University Medical Center, Nashville, Tennessee., Libos A; Vanderbilt University Medical Center, Nashville, Tennessee.; Now with Fundacion Santa Fe de Bogota, Colombia., Mitchell PM; Vanderbilt University Medical Center, Nashville, Tennessee., Moreno-Diaz AF; Vanderbilt University Medical Center, Nashville, Tennessee., Ponce RB; Vanderbilt University Medical Center, Nashville, Tennessee.; Now with Wright State University Boonshoft School of Medicine, Dayton, Ohio., Stinner DJ; Vanderbilt University Medical Center, Nashville, Tennessee., Tatman LM; Vanderbilt University Medical Center, Nashville, Tennessee., Velasco-Castro J; Vanderbilt University Medical Center, Nashville, Tennessee., Trochez K; Vanderbilt University Medical Center, Nashville, Tennessee., Satpathy J; Virginia Commonwealth University, Richmond., Zuelzer DA; Virginia Commonwealth University, Richmond., Potter BK; Walter Reed National Military Medical Center, Bethesda, Maryland.; Now with the University of Pennsylvania, Philadelphia.
Corporate Authors: Major Extremity Trauma Research Consortium (METRC)
Source: JAMA [JAMA] 2026 May 12; Vol. 335 (18), pp. 1586-1595.
Publication Type: Clinical Trial, Phase III; Comparative Study; Equivalence Trial; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Intrawound Tobramycin Plus Vancomycin to Prevent Surgical Site Infection in Tibial Fractures: The TOBRA Randomized Clinical Trial.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22O'Toole+RV%22">O'Toole RV</searchLink>; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.<br /><searchLink fieldCode="AU" term="%22O'Hara+NN%22">O'Hara NN</searchLink>; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.<br /><searchLink fieldCode="AU" term="%22Carlini+AR%22">Carlini AR</searchLink>; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Schrank+GM%22">Schrank GM</searchLink>; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.<br /><searchLink fieldCode="AU" term="%22Chung+S%22">Chung S</searchLink>; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Gary+JL%22">Gary JL</searchLink>; University of Southern California Keck School of Medicine, Los Angeles.<br /><searchLink fieldCode="AU" term="%22Obremskey+W%22">Obremskey W</searchLink>; Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Matuszewski+PE%22">Matuszewski PE</searchLink>; University of Kentucky, Lexington.<br /><searchLink fieldCode="AU" term="%22Teague+D%22">Teague D</searchLink>; University of Oklahoma Medical Center, Oklahoma City.<br /><searchLink fieldCode="AU" term="%22Natoli+RM%22">Natoli RM</searchLink>; Indiana University Health Methodist Hospital, Indianapolis.<br /><searchLink fieldCode="AU" term="%22Gitajn+IL%22">Gitajn IL</searchLink>; Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.<br /><searchLink fieldCode="AU" term="%22Weaver+MJ%22">Weaver MJ</searchLink>; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Renninger+CH%22">Renninger CH</searchLink>; Walter Reed National Military Medical Center, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Levack+AE%22">Levack AE</searchLink>; Loyola University Medical Center, Maywood, Illinois.<br /><searchLink fieldCode="AU" term="%22Degani+Y%22">Degani Y</searchLink>; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.<br /><searchLink fieldCode="AU" term="%22Collins+SC%22">Collins SC</searchLink>; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Weston-Farber+E%22">Weston-Farber E</searchLink>; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Howe+AL%22">Howe AL</searchLink>; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.<br /><searchLink fieldCode="AU" term="%22Thompson+RE%22">Thompson RE</searchLink>; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Castillo+RC%22">Castillo RC</searchLink>; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Karunakar+MA%22">Karunakar MA</searchLink>; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina.<br /><searchLink fieldCode="AU" term="%22Blum+L%22">Blum L</searchLink>; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina.<br /><searchLink fieldCode="AU" term="%22Harmer+L%22">Harmer L</searchLink>; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina.<br /><searchLink fieldCode="AU" term="%22Hsu+JR%22">Hsu JR</searchLink>; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina.<br /><searchLink fieldCode="AU" term="%22Kempton+LB%22">Kempton LB</searchLink>; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina.<br /><searchLink fieldCode="AU" term="%22Phelps+KD%22">Phelps KD</searchLink>; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina.<br /><searchLink fieldCode="AU" term="%22Seymour+RB%22">Seymour RB</searchLink>; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina.<br /><searchLink fieldCode="AU" term="%22Sims+SH%22">Sims SH</searchLink>; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina.<br /><searchLink fieldCode="AU" term="%22Acharya+MS%22">Acharya MS</searchLink>; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina.<br /><searchLink fieldCode="AU" term="%22Callahan+H%22">Callahan H</searchLink>; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina.<br /><searchLink fieldCode="AU" term="%22Chavez-Araujo+LM%22">Chavez-Araujo LM</searchLink>; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina.<br /><searchLink fieldCode="AU" term="%22Churchill+C%22">Churchill C</searchLink>; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina.<br /><searchLink fieldCode="AU" term="%22Gambuzza+MP%22">Gambuzza MP</searchLink>; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina.<br /><searchLink fieldCode="AU" term="%22Haim+KR%22">Haim KR</searchLink>; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina.<br /><searchLink fieldCode="AU" term="%22Ishman+E%22">Ishman E</searchLink>; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina.<br /><searchLink fieldCode="AU" term="%22Kendall+JS%22">Kendall JS</searchLink>; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina.; Now with Loma Linda School of Medicine, Loma Linda, California.<br /><searchLink fieldCode="AU" term="%22Mullis+ND%22">Mullis ND</searchLink>; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina.<br /><searchLink fieldCode="AU" term="%22Young+C%22">Young C</searchLink>; Atrium Health-Carolinas Medical Center, Charlotte, North Carolina.<br /><searchLink fieldCode="AU" term="%22Pilson+HT%22">Pilson HT</searchLink>; Atrium Health-Wake Forest Baptist, Winston-Salem, North Carolina.<br /><searchLink fieldCode="AU" term="%22Carroll+EA%22">Carroll EA</searchLink>; Atrium Health-Wake Forest Baptist, Winston-Salem, North Carolina.<br /><searchLink fieldCode="AU" term="%22Goodman+JB%22">Goodman JB</searchLink>; Atrium Health-Wake Forest Baptist, Winston-Salem, North Carolina.<br /><searchLink fieldCode="AU" term="%22Holden+MB%22">Holden MB</searchLink>; Atrium Health-Wake Forest Baptist, Winston-Salem, North Carolina.<br /><searchLink fieldCode="AU" term="%22Jones+AL%22">Jones AL</searchLink>; Baylor Scott & White Health, Dallas, Texas.<br /><searchLink fieldCode="AU" term="%22Moon+C%22">Moon C</searchLink>; Cedars-Sinai Medical Center, Los Angeles, California.<br /><searchLink fieldCode="AU" term="%22Lin+CA%22">Lin CA</searchLink>; Cedars-Sinai Medical Center, Los Angeles, California.<br /><searchLink fieldCode="AU" term="%22Marecek+GS%22">Marecek GS</searchLink>; Cedars-Sinai Medical Center, Los Angeles, California.<br /><searchLink fieldCode="AU" term="%22Moffitt+GB%22">Moffitt GB</searchLink>; Corewell Health, Grand Rapids, Michigan.<br /><searchLink fieldCode="AU" term="%22Conlan+T%22">Conlan T</searchLink>; Corewell Health, Grand Rapids, Michigan.<br /><searchLink fieldCode="AU" term="%22George+AV%22">George AV</searchLink>; Corewell Health, Grand Rapids, Michigan.<br /><searchLink fieldCode="AU" term="%22Fisher+LA%22">Fisher LA</searchLink>; Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.<br /><searchLink fieldCode="AU" term="%22Mullin+DS%22">Mullin DS</searchLink>; Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.<br /><searchLink fieldCode="AU" term="%22Recendez+CL%22">Recendez CL</searchLink>; Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.<br /><searchLink fieldCode="AU" term="%22Aneja+A%22">Aneja A</searchLink>; Harvard University, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Brameier+DT%22">Brameier DT</searchLink>; Harvard University, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Heng+M%22">Heng M</searchLink>; Harvard University, Boston, Massachusetts.; Now with Boston Medical Center-Brighton.<br /><searchLink fieldCode="AU" term="%22Ly+TV%22">Ly TV</searchLink>; Harvard University, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Stenquist+DS%22">Stenquist DS</searchLink>; Harvard University, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Suneja+N%22">Suneja N</searchLink>; Harvard University, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Wignakumar+T%22">Wignakumar T</searchLink>; Harvard University, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Borgida+JS%22">Borgida JS</searchLink>; Harvard University, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Policicchio+TJ%22">Policicchio TJ</searchLink>; Harvard University, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Hanson+GR%22">Hanson GR</searchLink>; Hennepin Healthcare, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Alese+OM%22">Alese OM</searchLink>; Hennepin Healthcare, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Ricci+WM%22">Ricci WM</searchLink>; Hospital of Special Surgery & NewYork-Presbyterian Hospital, New York.<br /><searchLink fieldCode="AU" term="%22Behrens+SB%22">Behrens SB</searchLink>; Hospital of Special Surgery & NewYork-Presbyterian Hospital, New York.<br /><searchLink fieldCode="AU" term="%22Dvorzhinskiy+A%22">Dvorzhinskiy A</searchLink>; Hospital of Special Surgery & NewYork-Presbyterian Hospital, New York.<br /><searchLink fieldCode="AU" term="%22Bilodeau+RE%22">Bilodeau RE</searchLink>; Hospital of Special Surgery & NewYork-Presbyterian Hospital, New York.<br /><searchLink fieldCode="AU" term="%22Klinger+CE%22">Klinger CE</searchLink>; Hospital of Special Surgery & NewYork-Presbyterian Hospital, New York.<br /><searchLink fieldCode="AU" term="%22Mullis+BH%22">Mullis BH</searchLink>; Indiana University Health Methodist Hospital, Indianapolis.<br /><searchLink fieldCode="AU" term="%22Jang+Y%22">Jang Y</searchLink>; Indiana University Health Methodist Hospital, Indianapolis.<br /><searchLink fieldCode="AU" term="%22Lopas+LA%22">Lopas LA</searchLink>; Indiana University Health Methodist Hospital, Indianapolis.<br /><searchLink fieldCode="AU" term="%22McKinley+TO%22">McKinley TO</searchLink>; Indiana University Health Methodist Hospital, Indianapolis.<br /><searchLink fieldCode="AU" term="%22O'Neill+DC%22">O'Neill DC</searchLink>; Indiana University Health Methodist Hospital, Indianapolis.<br /><searchLink fieldCode="AU" term="%22Szatkowski+JP%22">Szatkowski JP</searchLink>; Indiana University Health Methodist Hospital, Indianapolis.<br /><searchLink fieldCode="AU" term="%22Virkus+WW%22">Virkus WW</searchLink>; Indiana University Health Methodist Hospital, Indianapolis.<br /><searchLink fieldCode="AU" term="%22Hill+LC%22">Hill LC</searchLink>; Indiana University Health Methodist Hospital, Indianapolis.<br /><searchLink fieldCode="AU" term="%22Gaski+G%22">Gaski G</searchLink>; Inova Fairfax Medical Campus, Fairfax, Virginia.<br /><searchLink fieldCode="AU" term="%22Hymes+RA%22">Hymes RA</searchLink>; Inova Fairfax Medical Campus, Fairfax, Virginia.<br /><searchLink fieldCode="AU" term="%22Ahn+J%22">Ahn J</searchLink>; Inova Fairfax Medical Campus, Fairfax, Virginia.<br /><searchLink fieldCode="AU" term="%22Goch+AM%22">Goch AM</searchLink>; Inova Fairfax Medical Campus, Fairfax, Virginia.<br /><searchLink fieldCode="AU" term="%22Holzman+M%22">Holzman M</searchLink>; Inova Fairfax Medical Campus, Fairfax, Virginia.<br /><searchLink fieldCode="AU" term="%22Malekzadeh+AS%22">Malekzadeh AS</searchLink>; Inova Fairfax Medical Campus, Fairfax, Virginia.<br /><searchLink fieldCode="AU" term="%22Schulman+JE%22">Schulman JE</searchLink>; Inova Fairfax Medical Campus, Fairfax, Virginia.<br /><searchLink fieldCode="AU" term="%22Rivera+JC%22">Rivera JC</searchLink>; Louisiana State University, New Orleans.<br /><searchLink fieldCode="AU" term="%22Krause+PC%22">Krause PC</searchLink>; Louisiana State University, New Orleans.<br /><searchLink fieldCode="AU" term="%22Bridgman+C%22">Bridgman C</searchLink>; Louisiana State University, New Orleans.<br /><searchLink fieldCode="AU" term="%22Cohen+J%22">Cohen J</searchLink>; Loyola University Medical Center, Maywood, Illinois.<br /><searchLink fieldCode="AU" term="%22Eikani+C%22">Eikani C</searchLink>; Loyola University Medical Center, Maywood, Illinois.<br /><searchLink fieldCode="AU" term="%22Chavez+M%22">Chavez M</searchLink>; Loyola University Medical Center, Maywood, Illinois.<br /><searchLink fieldCode="AU" term="%22Kudulis+M%22">Kudulis M</searchLink>; Loyola University Medical Center, Maywood, Illinois.<br /><searchLink fieldCode="AU" term="%22Warner+SJ%22">Warner SJ</searchLink>; McGovern Medical School at the University of Texas Health Science Center at Houston.<br /><searchLink fieldCode="AU" term="%22Achor+TS%22">Achor TS</searchLink>; McGovern Medical School at the University of Texas Health Science Center at Houston.<br /><searchLink fieldCode="AU" term="%22Choo+A%22">Choo A</searchLink>; McGovern Medical School at the University of Texas Health Science Center at Houston.<br /><searchLink fieldCode="AU" term="%22Eastman+JG%22">Eastman JG</searchLink>; McGovern Medical School at the University of Texas Health Science Center at Houston.<br /><searchLink fieldCode="AU" term="%22Kellam+PJ%22">Kellam PJ</searchLink>; McGovern Medical School at the University of Texas Health Science Center at Houston.<br /><searchLink fieldCode="AU" term="%22Boutte+SJ%22">Boutte SJ</searchLink>; McGovern Medical School at the University of Texas Health Science Center at Houston.<br /><searchLink fieldCode="AU" term="%22Guevara+KD%22">Guevara KD</searchLink>; McGovern Medical School at the University of Texas Health Science Center at Houston.<br /><searchLink fieldCode="AU" term="%22Reid+KR%22">Reid KR</searchLink>; Medical University of South Carolina, Charleston.<br /><searchLink fieldCode="AU" term="%22Vallier+HA%22">Vallier HA</searchLink>; MetroHealth Medical Center, Cleveland, Ohio.<br /><searchLink fieldCode="AU" term="%22Tucci+AV%22">Tucci AV</searchLink>; MetroHealth Medical Center, Cleveland, Ohio.<br /><searchLink fieldCode="AU" term="%22Davis+JM%22">Davis JM</searchLink>; Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Bell+AC%22">Bell AC</searchLink>; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.<br /><searchLink fieldCode="AU" term="%22Bonyun+ME%22">Bonyun ME</searchLink>; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.<br /><searchLink fieldCode="AU" term="%22Healey+K%22">Healey K</searchLink>; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.<br /><searchLink fieldCode="AU" term="%22Li+V%22">Li V</searchLink>; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.; Now with University of Texas Southwestern, Dallas.<br /><searchLink fieldCode="AU" term="%22McKibben+NS%22">McKibben NS</searchLink>; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.; Now with Oregon Health & Science University, Portland.<br /><searchLink fieldCode="AU" term="%22Nascone+J%22">Nascone J</searchLink>; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.<br /><searchLink fieldCode="AU" term="%22Okhuereigbe+D%22">Okhuereigbe D</searchLink>; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.<br /><searchLink fieldCode="AU" term="%22Sciadini+MF%22">Sciadini MF</searchLink>; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.<br /><searchLink fieldCode="AU" term="%22Slobogean+G%22">Slobogean G</searchLink>; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.; Now with University of California, Irvine.<br /><searchLink fieldCode="AU" term="%22Zingas+N%22">Zingas N</searchLink>; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.<br /><searchLink fieldCode="AU" term="%22Kovvur+M%22">Kovvur M</searchLink>; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.; Now with University of Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Lawrence+JE%22">Lawrence JE</searchLink>; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.; Now with MedStar Health, Washington, DC.<br /><searchLink fieldCode="AU" term="%22Phipps+H%22">Phipps H</searchLink>; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.<br /><searchLink fieldCode="AU" term="%22Rudnicki+J%22">Rudnicki J</searchLink>; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.; Now with Johns Hopkins Hospital, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Turner+KE%22">Turner KE</searchLink>; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore.; Now with Georgetown University, Washington, DC.<br /><searchLink fieldCode="AU" term="%22Hayda+R%22">Hayda R</searchLink>; Rhode Island Hospital at Brown University, Providence.<br /><searchLink fieldCode="AU" term="%22Evans+AR%22">Evans AR</searchLink>; Rhode Island Hospital at Brown University, Providence.<br /><searchLink fieldCode="AU" term="%22Quinnan+S%22">Quinnan S</searchLink>; St Mary's Medical Center, West Palm Beach, Florida.<br /><searchLink fieldCode="AU" term="%22Benitez+A%22">Benitez A</searchLink>; St Mary's Medical Center, West Palm Beach, Florida.<br /><searchLink fieldCode="AU" term="%22Rehman+S%22">Rehman S</searchLink>; Temple University Hospital, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Soderquist+MC%22">Soderquist MC</searchLink>; Temple University Hospital, Philadelphia, Pennsylvania.; Now with Robert Wood Johnson Barnabas Health, Jersey City, New Jersey.<br /><searchLink fieldCode="AU" term="%22Townsend+CB%22">Townsend CB</searchLink>; Temple University Hospital, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Caroom+C%22">Caroom C</searchLink>; Texas Tech University Health Sciences Center, Lubbock.<br /><searchLink fieldCode="AU" term="%22Collins+AC%22">Collins AC</searchLink>; Ohio State University Medical Center, Columbus.<br /><searchLink fieldCode="AU" term="%22Okwumabua+E%22">Okwumabua E</searchLink>; Ohio State University Medical Center, Columbus.<br /><searchLink fieldCode="AU" term="%22Shaikh+HS%22">Shaikh HS</searchLink>; Ohio State University Medical Center, Columbus.<br /><searchLink fieldCode="AU" term="%22Spitler+CA%22">Spitler CA</searchLink>; University of Alabama at Birmingham.<br /><searchLink fieldCode="AU" term="%22Agarwal+A%22">Agarwal A</searchLink>; University of Alabama at Birmingham.<br /><searchLink fieldCode="AU" term="%22Johnson+MD%22">Johnson MD</searchLink>; University of Alabama at Birmingham.<br /><searchLink fieldCode="AU" term="%22Haller+JM%22">Haller JM</searchLink>; University of Utah, Salt Lake City.<br /><searchLink fieldCode="AU" term="%22Marchand+LS%22">Marchand LS</searchLink>; University of Utah, Salt Lake City.<br /><searchLink fieldCode="AU" term="%22Alfonso+NA%22">Alfonso NA</searchLink>; University of Colorado Medicine, Aurora.<br /><searchLink fieldCode="AU" term="%22Gorman+MA%22">Gorman MA</searchLink>; University of Colorado Medicine, Aurora.<br /><searchLink fieldCode="AU" term="%22Charlton+WM%22">Charlton WM</searchLink>; University of Kentucky, Lexington.<br /><searchLink fieldCode="AU" term="%22Scott+BR%22">Scott BR</searchLink>; University of Kentucky, Lexington.<br /><searchLink fieldCode="AU" term="%22Kraus+KM%22">Kraus KM</searchLink>; University of Kentucky, Lexington.<br /><searchLink fieldCode="AU" term="%22Meredith+SJ%22">Meredith SJ</searchLink>; University of Maryland Capital Region Health, Largo.<br /><searchLink fieldCode="AU" term="%22Talwar+S%22">Talwar S</searchLink>; University of Maryland Capital Region Health, Largo.<br /><searchLink fieldCode="AU" term="%22Bergin+PF%22">Bergin PF</searchLink>; University of Mississippi Medical Center, Jackson.<br /><searchLink fieldCode="AU" term="%22Jha+AJ%22">Jha AJ</searchLink>; University of Mississippi Medical Center, Jackson.; Now with Maimonides Medical Center, Brooklyn, New York.<br /><searchLink fieldCode="AU" term="%22McGee+S%22">McGee S</searchLink>; University of Mississippi Medical Center, Jackson.<br /><searchLink fieldCode="AU" term="%22Nehete+PV%22">Nehete PV</searchLink>; University of Mississippi Medical Center, Jackson.<br /><searchLink fieldCode="AU" term="%22Pryor+TA%22">Pryor TA</searchLink>; University of Mississippi Medical Center, Jackson.<br /><searchLink fieldCode="AU" term="%22Spears+I%22">Spears I</searchLink>; University of Mississippi Medical Center, Jackson.<br /><searchLink fieldCode="AU" term="%22Chen+AT%22">Chen AT</searchLink>; University of North Carolina School of Medicine, Chapel Hill.<br /><searchLink fieldCode="AU" term="%22Kelley+B%22">Kelley B</searchLink>; University of North Carolina School of Medicine, Chapel Hill.<br /><searchLink fieldCode="AU" term="%22Nez+NR%22">Nez NR</searchLink>; University of North Carolina School of Medicine, Chapel Hill.<br /><searchLink fieldCode="AU" term="%22Ertl+WJ%22">Ertl WJ</searchLink>; University of Oklahoma Medical Center, Oklahoma City.<br /><searchLink fieldCode="AU" term="%22Hull+BR%22">Hull BR</searchLink>; University of Oklahoma Medical Center, Oklahoma City.<br /><searchLink fieldCode="AU" term="%22Blumenthal+S%22">Blumenthal S</searchLink>; University of Southern California Keck School of Medicine, Los Angeles.<br /><searchLink fieldCode="AU" term="%22Patterson+JT%22">Patterson JT</searchLink>; University of Southern California Keck School of Medicine, Los Angeles.<br /><searchLink fieldCode="AU" term="%22Flynn+C%22">Flynn C</searchLink>; University of Southern California Keck School of Medicine, Los Angeles.<br /><searchLink fieldCode="AU" term="%22Ross+RC%22">Ross RC</searchLink>; University of Southern California Keck School of Medicine, Los Angeles.<br /><searchLink fieldCode="AU" term="%22Agarwal+A%22">Agarwal A</searchLink>; University of Texas Health Sciences Center, San Antonio.<br /><searchLink fieldCode="AU" term="%22Weiss+DB%22">Weiss DB</searchLink>; University of Virginia Medical Center, Charlottesville.<br /><searchLink fieldCode="AU" term="%22Hadeed+MM%22">Hadeed MM</searchLink>; University of Virginia Medical Center, Charlottesville.<br /><searchLink fieldCode="AU" term="%22Yarboro+SR%22">Yarboro SR</searchLink>; University of Virginia Medical Center, Charlottesville.<br /><searchLink fieldCode="AU" term="%22Daoud+T%22">Daoud T</searchLink>; University of Virginia Medical Center, Charlottesville.<br /><searchLink fieldCode="AU" term="%22McVey+ED%22">McVey ED</searchLink>; University of Virginia Medical Center, Charlottesville.<br /><searchLink fieldCode="AU" term="%22Whiting+PS%22">Whiting PS</searchLink>; University of Wisconsin, Madison.<br /><searchLink fieldCode="AU" term="%22Domes+C%22">Domes C</searchLink>; University of Wisconsin, Madison.<br /><searchLink fieldCode="AU" term="%22Goodspeed+DC%22">Goodspeed DC</searchLink>; University of Wisconsin, Madison.<br /><searchLink fieldCode="AU" term="%22Kuhn+GR%22">Kuhn GR</searchLink>; University of Wisconsin, Madison.<br /><searchLink fieldCode="AU" term="%22Boyce+R%22">Boyce R</searchLink>; Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Libos+A%22">Libos A</searchLink>; Vanderbilt University Medical Center, Nashville, Tennessee.; Now with Fundacion Santa Fe de Bogota, Colombia.<br /><searchLink fieldCode="AU" term="%22Mitchell+PM%22">Mitchell PM</searchLink>; Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Moreno-Diaz+AF%22">Moreno-Diaz AF</searchLink>; Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Ponce+RB%22">Ponce RB</searchLink>; Vanderbilt University Medical Center, Nashville, Tennessee.; Now with Wright State University Boonshoft School of Medicine, Dayton, Ohio.<br /><searchLink fieldCode="AU" term="%22Stinner+DJ%22">Stinner DJ</searchLink>; Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Tatman+LM%22">Tatman LM</searchLink>; Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Velasco-Castro+J%22">Velasco-Castro J</searchLink>; Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Trochez+K%22">Trochez K</searchLink>; Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Satpathy+J%22">Satpathy J</searchLink>; Virginia Commonwealth University, Richmond.<br /><searchLink fieldCode="AU" term="%22Zuelzer+DA%22">Zuelzer DA</searchLink>; Virginia Commonwealth University, Richmond.<br /><searchLink fieldCode="AU" term="%22Potter+BK%22">Potter BK</searchLink>; Walter Reed National Military Medical Center, Bethesda, Maryland.; Now with the University of Pennsylvania, Philadelphia.
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  Data: <searchLink fieldCode="CA" term="%22Major+Extremity+Trauma+Research+Consortium+%28METRC%29%22">Major Extremity Trauma Research Consortium (METRC)</searchLink>
– Name: TitleSource
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  Data: <searchLink fieldCode="JN" term="%227501160%22">JAMA</searchLink> [JAMA] 2026 May 12; Vol. 335 (18), pp. 1586-1595.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Clinical Trial, Phase III; Comparative Study; Equivalence Trial; Journal Article; Multicenter Study; Randomized Controlled Trial
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Medical+Association%22">American Medical Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7501160 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1538-3598 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200987484%22">00987484 </searchLink><i>NLM ISO Abbreviation: </i>JAMA <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41984450
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        Value: 10.1001/jama.2026.4023
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      – Code: eng
        Text: English
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        StartPage: 1586
    Titles:
      – TitleFull: Intrawound Tobramycin Plus Vancomycin to Prevent Surgical Site Infection in Tibial Fractures: The TOBRA Randomized Clinical Trial.
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    IsPartOfRelationships:
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          Dates:
            – D: 12
              M: 05
              Text: 2026 May 12
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1538-3598
          Numbering:
            – Type: volume
              Value: 335
            – Type: issue
              Value: 18
          Titles:
            – TitleFull: JAMA
              Type: main
ResultId 1