Obesity-driven phosphatidylethanolamine dysregulation impairs neuroimmune crosstalk and accelerates Alzheimer's pathogenesis.

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Title: Obesity-driven phosphatidylethanolamine dysregulation impairs neuroimmune crosstalk and accelerates Alzheimer's pathogenesis.
Authors: Yang L; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA. lyang@houstonmethodist.org.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA. lyang@houstonmethodist.org., Sheng J; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA. jsheng@houstonmethodist.org.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA. jsheng@houstonmethodist.org.; Departments of Pathology and Laboratory Medicine and Radiology, Houston Methodist Hospital and Weill Cornell Medicine, Houston, TX, 77030, USA. jsheng@houstonmethodist.org., Qi S; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA., Yin Z; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA., Chan M; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA., Cao Y; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA., Zhao H; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA., Wan Z; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA., Chan B; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA., Ahn JY; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA., Yu X; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA., Vasquez M; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA., Xu S; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA., Han X; Barshop Institute for Longevity and Aging Studies, and Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Xia W; Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118, USA.; Geriatric Research Education and Clinical Center, Bedford VA Healthcare System, Bedford, MA, 01730, USA., Hsueh WA; Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes & Metabolism, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA., Wong STC; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA. stwong@houstonmethodist.org.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA. stwong@houstonmethodist.org.; Departments of Pathology and Laboratory Medicine and Radiology, Houston Methodist Hospital and Weill Cornell Medicine, Houston, TX, 77030, USA. stwong@houstonmethodist.org.
Source: Molecular neurodegeneration [Mol Neurodegener] 2026 Apr 15; Vol. 21 (1). Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326 (Electronic) Linking ISSN: 17501326 NLM ISO Abbreviation: Mol Neurodegener Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1750-1326
DOI:10.1186/s13024-026-00943-3