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Obesity-driven phosphatidylethanolamine dysregulation impairs neuroimmune crosstalk and accelerates Alzheimer's pathogenesis.

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Title: Obesity-driven phosphatidylethanolamine dysregulation impairs neuroimmune crosstalk and accelerates Alzheimer's pathogenesis.
Authors: Yang L; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA. lyang@houstonmethodist.org.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA. lyang@houstonmethodist.org., Sheng J; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA. jsheng@houstonmethodist.org.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA. jsheng@houstonmethodist.org.; Departments of Pathology and Laboratory Medicine and Radiology, Houston Methodist Hospital and Weill Cornell Medicine, Houston, TX, 77030, USA. jsheng@houstonmethodist.org., Qi S; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA., Yin Z; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA., Chan M; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA., Cao Y; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA., Zhao H; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA., Wan Z; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA., Chan B; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA., Ahn JY; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA., Yu X; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA., Vasquez M; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA., Xu S; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA., Han X; Barshop Institute for Longevity and Aging Studies, and Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Xia W; Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118, USA.; Geriatric Research Education and Clinical Center, Bedford VA Healthcare System, Bedford, MA, 01730, USA., Hsueh WA; Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes & Metabolism, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA., Wong STC; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA. stwong@houstonmethodist.org.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA. stwong@houstonmethodist.org.; Departments of Pathology and Laboratory Medicine and Radiology, Houston Methodist Hospital and Weill Cornell Medicine, Houston, TX, 77030, USA. stwong@houstonmethodist.org.
Source: Molecular neurodegeneration [Mol Neurodegener] 2026 Apr 15; Vol. 21 (1). Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326 (Electronic) Linking ISSN: 17501326 NLM ISO Abbreviation: Mol Neurodegener Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Obesity-driven phosphatidylethanolamine dysregulation impairs neuroimmune crosstalk and accelerates Alzheimer's pathogenesis.
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  Data: <searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA. lyang@houstonmethodist.org.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA. lyang@houstonmethodist.org.<br /><searchLink fieldCode="AU" term="%22Sheng+J%22">Sheng J</searchLink>; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA. jsheng@houstonmethodist.org.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA. jsheng@houstonmethodist.org.; Departments of Pathology and Laboratory Medicine and Radiology, Houston Methodist Hospital and Weill Cornell Medicine, Houston, TX, 77030, USA. jsheng@houstonmethodist.org.<br /><searchLink fieldCode="AU" term="%22Qi+S%22">Qi S</searchLink>; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Yin+Z%22">Yin Z</searchLink>; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Chan+M%22">Chan M</searchLink>; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Cao+Y%22">Cao Y</searchLink>; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+H%22">Zhao H</searchLink>; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Wan+Z%22">Wan Z</searchLink>; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Chan+B%22">Chan B</searchLink>; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Ahn+JY%22">Ahn JY</searchLink>; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Yu+X%22">Yu X</searchLink>; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Vasquez+M%22">Vasquez M</searchLink>; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Xu+S%22">Xu S</searchLink>; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Han+X%22">Han X</searchLink>; Barshop Institute for Longevity and Aging Studies, and Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Xia+W%22">Xia W</searchLink>; Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118, USA.; Geriatric Research Education and Clinical Center, Bedford VA Healthcare System, Bedford, MA, 01730, USA.<br /><searchLink fieldCode="AU" term="%22Hsueh+WA%22">Hsueh WA</searchLink>; Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes & Metabolism, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.<br /><searchLink fieldCode="AU" term="%22Wong+STC%22">Wong STC</searchLink>; Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Academic Institute and Weill Cornell Medicine, Houston, TX, 77030, USA. stwong@houstonmethodist.org.; Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, 77030, USA. stwong@houstonmethodist.org.; Departments of Pathology and Laboratory Medicine and Radiology, Houston Methodist Hospital and Weill Cornell Medicine, Houston, TX, 77030, USA. stwong@houstonmethodist.org.
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  Data: <searchLink fieldCode="JN" term="%22101266600%22">Molecular neurodegeneration</searchLink> [Mol Neurodegener] 2026 Apr 15; Vol. 21 (1). <i>Date of Electronic Publication: </i>2026 Apr 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101266600 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1750-1326 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217501326%22">17501326 </searchLink><i>NLM ISO Abbreviation: </i>Mol Neurodegener <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s13024-026-00943-3
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