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Cross-species metabolic characterization of eutylone and mechanism-based inhibition of CYP2D6 and CYP2B6 with drug interaction implications.

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Title: Cross-species metabolic characterization of eutylone and mechanism-based inhibition of CYP2D6 and CYP2B6 with drug interaction implications.
Authors: Lee MS; College of Pharmacy, The Catholic University of Korea, Bucheon, 14662, Republic of Korea., Song IS; BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, Vessel-Organ Interaction Research Center (VOICE), Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, Daegu, 41566, Republic of Korea., Jang Y; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Republic of Korea., Cho YY; College of Pharmacy, The Catholic University of Korea, Bucheon, 14662, Republic of Korea., Lee JY; College of Pharmacy, The Catholic University of Korea, Bucheon, 14662, Republic of Korea., Kang HC; College of Pharmacy, The Catholic University of Korea, Bucheon, 14662, Republic of Korea., Kim JH; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Republic of Korea. jhkim@yu.ac.kr., Lee HS; College of Pharmacy, The Catholic University of Korea, Bucheon, 14662, Republic of Korea. sianalee@catholic.ac.kr.
Source: Scientific reports [Sci Rep] 2026 Apr 16; Vol. 16 (1). Date of Electronic Publication: 2026 Apr 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2045-2322
DOI:10.1038/s41598-026-48814-7