Cryo-EM structures of higher order Gephyrin oligomers reveal principles of inhibitory postsynaptic scaffold organization.

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Title: Cryo-EM structures of higher order Gephyrin oligomers reveal principles of inhibitory postsynaptic scaffold organization.
Authors: Ortiz-López D; University of Würzburg, Rudolf Virchow Center for Integrative and Translational Bioimaging, Josef-Schneider-Str. 2, Würzburg, Germany., Hove TT; University of Würzburg, Rudolf Virchow Center for Integrative and Translational Bioimaging, Josef-Schneider-Str. 2, Würzburg, Germany., Huhn C; University of Würzburg, Rudolf Virchow Center for Integrative and Translational Bioimaging, Josef-Schneider-Str. 2, Würzburg, Germany., Camuso S; Neuro-Bicêtre, Inserm U1195, Université Paris-Saclay, Bâtiment Gregory Pincus, 80 Rue du Général Leclerc, Le Kremlin-Bicêtre, France., van Gen Hassend PM; University of Würzburg, Rudolf Virchow Center for Integrative and Translational Bioimaging, Josef-Schneider-Str. 2, Würzburg, Germany., Sander B; University of Würzburg, Rudolf Virchow Center for Integrative and Translational Bioimaging, Josef-Schneider-Str. 2, Würzburg, Germany.; CSL Innovation GmbH, Marburg, Germany., Campbell BFN; University of Zürich, Institute of Pharmacology and Toxicology, Winterthurerstr. 190, Zürich, Switzerland., Tyagarajan SK; University of Zürich, Institute of Pharmacology and Toxicology, Winterthurerstr. 190, Zürich, Switzerland.; Department of Life Sciences, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal., Plückthun A; University of Zürich, Department of Biochemistry, Winterthurerstr. 190, Zürich, Switzerland., Specht CG; Neuro-Bicêtre, Inserm U1195, Université Paris-Saclay, Bâtiment Gregory Pincus, 80 Rue du Général Leclerc, Le Kremlin-Bicêtre, France., Maric HM; University of Würzburg, Rudolf Virchow Center for Integrative and Translational Bioimaging, Josef-Schneider-Str. 2, Würzburg, Germany., Böttcher B; University of Würzburg, Rudolf Virchow Center for Integrative and Translational Bioimaging, Josef-Schneider-Str. 2, Würzburg, Germany., Schindelin H; University of Würzburg, Rudolf Virchow Center for Integrative and Translational Bioimaging, Josef-Schneider-Str. 2, Würzburg, Germany. hermann.schindelin@uni-wuerzburg.de.
Source: Nature communications [Nat Commun] 2026 Apr 16; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-026-71771-8