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Discovery of an Endonuclease G-inhibitory Ku80-peptide protecting against leukemogenic rearrangements at the MLL breakpoint cluster.

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Title: Discovery of an Endonuclease G-inhibitory Ku80-peptide protecting against leukemogenic rearrangements at the MLL breakpoint cluster.
Authors: Eberle J; Department of Obstetrics and Gynecology, Ulm University, Ulm, Germany., Salem A; Department of Obstetrics and Gynecology, Ulm University, Ulm, Germany., Hofmann M; Department of Physics, Institute of Biophysics, Ulm University, Ulm, Germany.; Department of Physics, Institute of Experimental Physics, Ulm University, Ulm, Germany., Reisser A; Department of Physics, Institute of Biophysics, Ulm University, Ulm, Germany., Ruiz-Blanco YB; Department of Biology, Computational Biochemistry, University of Duisburg-Essen, Essen, Germany., Almeida-Hernandez Y; Department of Biochemical and Chemical Engineering, Chair of Computational Bioengineering, Technical University Dortmund, Dortmund, Germany., Gole B; Department of Obstetrics and Gynecology, Ulm University, Ulm, Germany.; Centre for human molecular genetics and pharmacogenomics, Faculty of Medicine, University of Maribor, SI, Maribor, Slovenia., Rall-Scharpf M; Department of Obstetrics and Gynecology, Ulm University, Ulm, Germany., Angulo-Capel J; Department of Physics, Institute of Biophysics, Ulm University, Ulm, Germany.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 149-153, Barcelona, Spain., Monecke T; Institute of Pharmaceutical Biotechnology, Ulm University, James-Franck-Ring N27, Ulm, Germany., Sanchez-Garcia E; Department of Biology, Computational Biochemistry, University of Duisburg-Essen, Essen, Germany. elsa.sanchez@tu-dortmund.de.; Department of Biochemical and Chemical Engineering, Chair of Computational Bioengineering, Technical University Dortmund, Dortmund, Germany. elsa.sanchez@tu-dortmund.de., Gebhardt JCM; Department of Physics, Institute of Biophysics, Ulm University, Ulm, Germany. christof.gebhardt@uni-ulm.de.; Department of Physics, Institute of Experimental Physics, Ulm University, Ulm, Germany. christof.gebhardt@uni-ulm.de., Wiesmüller L; Department of Obstetrics and Gynecology, Ulm University, Ulm, Germany. lisa.wiesmueller@uni-ulm.de.
Source: Nature communications [Nat Commun] 2026 Apr 17; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of an Endonuclease G-inhibitory Ku80-peptide protecting against leukemogenic rearrangements at the MLL breakpoint cluster.
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  Data: <searchLink fieldCode="AU" term="%22Eberle+J%22">Eberle J</searchLink>; Department of Obstetrics and Gynecology, Ulm University, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Salem+A%22">Salem A</searchLink>; Department of Obstetrics and Gynecology, Ulm University, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Hofmann+M%22">Hofmann M</searchLink>; Department of Physics, Institute of Biophysics, Ulm University, Ulm, Germany.; Department of Physics, Institute of Experimental Physics, Ulm University, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Reisser+A%22">Reisser A</searchLink>; Department of Physics, Institute of Biophysics, Ulm University, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Ruiz-Blanco+YB%22">Ruiz-Blanco YB</searchLink>; Department of Biology, Computational Biochemistry, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Almeida-Hernandez+Y%22">Almeida-Hernandez Y</searchLink>; Department of Biochemical and Chemical Engineering, Chair of Computational Bioengineering, Technical University Dortmund, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Gole+B%22">Gole B</searchLink>; Department of Obstetrics and Gynecology, Ulm University, Ulm, Germany.; Centre for human molecular genetics and pharmacogenomics, Faculty of Medicine, University of Maribor, SI, Maribor, Slovenia.<br /><searchLink fieldCode="AU" term="%22Rall-Scharpf+M%22">Rall-Scharpf M</searchLink>; Department of Obstetrics and Gynecology, Ulm University, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Angulo-Capel+J%22">Angulo-Capel J</searchLink>; Department of Physics, Institute of Biophysics, Ulm University, Ulm, Germany.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 149-153, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Monecke+T%22">Monecke T</searchLink>; Institute of Pharmaceutical Biotechnology, Ulm University, James-Franck-Ring N27, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Sanchez-Garcia+E%22">Sanchez-Garcia E</searchLink>; Department of Biology, Computational Biochemistry, University of Duisburg-Essen, Essen, Germany. elsa.sanchez@tu-dortmund.de.; Department of Biochemical and Chemical Engineering, Chair of Computational Bioengineering, Technical University Dortmund, Dortmund, Germany. elsa.sanchez@tu-dortmund.de.<br /><searchLink fieldCode="AU" term="%22Gebhardt+JCM%22">Gebhardt JCM</searchLink>; Department of Physics, Institute of Biophysics, Ulm University, Ulm, Germany. christof.gebhardt@uni-ulm.de.; Department of Physics, Institute of Experimental Physics, Ulm University, Ulm, Germany. christof.gebhardt@uni-ulm.de.<br /><searchLink fieldCode="AU" term="%22Wiesmüller+L%22">Wiesmüller L</searchLink>; Department of Obstetrics and Gynecology, Ulm University, Ulm, Germany. lisa.wiesmueller@uni-ulm.de.
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