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NAT10 promotes gallbladder cancer progression by remodeling cholesterol metabolism via PCSK9 mRNA acetylation.

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Title: NAT10 promotes gallbladder cancer progression by remodeling cholesterol metabolism via PCSK9 mRNA acetylation.
Authors: Chen ZY; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China., Wang MY; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China., Ma B; Department of Gastrointestinal Surgery, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Zhao C; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China., Pan LJ; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China., Wang ZY; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China., Wang YT; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China., Mao PY; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China., Zhao X; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China., Qin DL; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China., Shu YJ; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China. shuyijun19881125@163.com.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China. shuyijun19881125@163.com., Zhang YJ; Department of Cardio-Thoracic Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China. Zyjcpb@126.com., Xiang SS; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China. xiangshanshan1989@163.com.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China. xiangshanshan1989@163.com., Dong P; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China. dongping@xinhuamed.com.cn.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China. dongping@xinhuamed.com.cn.
Source: Cell death discovery [Cell Death Discov] 2026 Apr 16; Vol. 12 (1). Date of Electronic Publication: 2026 Apr 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: NAT10 promotes gallbladder cancer progression by remodeling cholesterol metabolism via PCSK9 mRNA acetylation.
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  Data: <searchLink fieldCode="AU" term="%22Chen+ZY%22">Chen ZY</searchLink>; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+MY%22">Wang MY</searchLink>; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Ma+B%22">Ma B</searchLink>; Department of Gastrointestinal Surgery, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhao+C%22">Zhao C</searchLink>; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Pan+LJ%22">Pan LJ</searchLink>; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+ZY%22">Wang ZY</searchLink>; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+YT%22">Wang YT</searchLink>; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Mao+PY%22">Mao PY</searchLink>; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhao+X%22">Zhao X</searchLink>; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Qin+DL%22">Qin DL</searchLink>; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Shu+YJ%22">Shu YJ</searchLink>; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China. shuyijun19881125@163.com.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China. shuyijun19881125@163.com.<br /><searchLink fieldCode="AU" term="%22Zhang+YJ%22">Zhang YJ</searchLink>; Department of Cardio-Thoracic Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China. Zyjcpb@126.com.<br /><searchLink fieldCode="AU" term="%22Xiang+SS%22">Xiang SS</searchLink>; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China. xiangshanshan1989@163.com.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China. xiangshanshan1989@163.com.<br /><searchLink fieldCode="AU" term="%22Dong+P%22">Dong P</searchLink>; Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China. dongping@xinhuamed.com.cn.; Shanghai Key Laboratory of Biliary Tract Disease Research, China, Shanghai, China. dongping@xinhuamed.com.cn.
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  Data: <searchLink fieldCode="JN" term="%22101665035%22">Cell death discovery</searchLink> [Cell Death Discov] 2026 Apr 16; Vol. 12 (1). <i>Date of Electronic Publication: </i>2026 Apr 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101665035 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2058-7716 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220587716%22">20587716 </searchLink><i>NLM ISO Abbreviation: </i>Cell Death Discov <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41991932
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1038/s41420-026-03104-z
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      – Code: eng
        Text: English
    Titles:
      – TitleFull: NAT10 promotes gallbladder cancer progression by remodeling cholesterol metabolism via PCSK9 mRNA acetylation.
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            – D: 16
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              Text: 2026 Apr 16
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              Y: 2026
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