TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950.
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| Title: | TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950. |
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| Authors: | Lackner A; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Picucci SI; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Jiang W; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Onyuru J; Division of Pediatric Allergy, Immunology, and Rheumatology, Rady Children's Hospital of San Diego, University of California San Diego School of Medicine, San Diego, CA, USA., Campos M; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Cabral JE; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Leonidas L; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Macapagal A; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Lee H; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Henriquez V; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Wang K; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Xu H; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Qiu Y; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Albrecht LV; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA.; Department of Pharmaceutical Sciences, University of California, Irvine, CA, USA., Hoffman HM; Division of Pediatric Allergy, Immunology, and Rheumatology, Rady Children's Hospital of San Diego, University of California San Diego School of Medicine, San Diego, CA, USA., McNulty R; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA. rmcnulty@uci.edu.; Department of Pharmaceutical Sciences, University of California, Irvine, CA, USA. rmcnulty@uci.edu. |
| Source: | Communications biology [Commun Biol] 2026 Apr 16; Vol. 9 (1). Date of Electronic Publication: 2026 Apr 16. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2399-3642 |
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| DOI: | 10.1038/s42003-026-10008-2 |
