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TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950.

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Title: TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950.
Authors: Lackner A; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Picucci SI; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Jiang W; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Onyuru J; Division of Pediatric Allergy, Immunology, and Rheumatology, Rady Children's Hospital of San Diego, University of California San Diego School of Medicine, San Diego, CA, USA., Campos M; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Cabral JE; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Leonidas L; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Macapagal A; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Lee H; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Henriquez V; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Wang K; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Xu H; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Qiu Y; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Albrecht LV; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA.; Department of Pharmaceutical Sciences, University of California, Irvine, CA, USA., Hoffman HM; Division of Pediatric Allergy, Immunology, and Rheumatology, Rady Children's Hospital of San Diego, University of California San Diego School of Medicine, San Diego, CA, USA., McNulty R; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA. rmcnulty@uci.edu.; Department of Pharmaceutical Sciences, University of California, Irvine, CA, USA. rmcnulty@uci.edu.
Source: Communications biology [Commun Biol] 2026 Apr 16; Vol. 9 (1). Date of Electronic Publication: 2026 Apr 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950.
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  Data: <searchLink fieldCode="AU" term="%22Lackner+A%22">Lackner A</searchLink>; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Picucci+SI%22">Picucci SI</searchLink>; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+W%22">Jiang W</searchLink>; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Onyuru+J%22">Onyuru J</searchLink>; Division of Pediatric Allergy, Immunology, and Rheumatology, Rady Children's Hospital of San Diego, University of California San Diego School of Medicine, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Campos+M%22">Campos M</searchLink>; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cabral+JE%22">Cabral JE</searchLink>; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Leonidas+L%22">Leonidas L</searchLink>; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Macapagal+A%22">Macapagal A</searchLink>; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+H%22">Lee H</searchLink>; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Henriquez+V%22">Henriquez V</searchLink>; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+K%22">Wang K</searchLink>; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Xu+H%22">Xu H</searchLink>; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Qiu+Y%22">Qiu Y</searchLink>; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Albrecht+LV%22">Albrecht LV</searchLink>; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA.; Department of Pharmaceutical Sciences, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hoffman+HM%22">Hoffman HM</searchLink>; Division of Pediatric Allergy, Immunology, and Rheumatology, Rady Children's Hospital of San Diego, University of California San Diego School of Medicine, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22McNulty+R%22">McNulty R</searchLink>; Laboratory of Macromolecular Structure, Department of Molecular Biology & Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA. rmcnulty@uci.edu.; Department of Pharmaceutical Sciences, University of California, Irvine, CA, USA. rmcnulty@uci.edu.
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