Combined multi-omics and multi-spectral profiling of plasma extracellular vesicles reveals liquid biopsy biomarkers for glioma diagnosis.

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Title: Combined multi-omics and multi-spectral profiling of plasma extracellular vesicles reveals liquid biopsy biomarkers for glioma diagnosis.
Authors: Robinson SD; Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK; Sussex Cancer Centre, University Hospitals Sussex NHS Foundation Trust, Brighton BN2 5BE, UK. Electronic address: s.d.robinson@sussex.ac.uk., Haile BT; Bioinformatics Laboratory, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK., Reily-Bell M; Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand., Iwanowytsch O; NanoOmics Lab, Centre for Nanotechnology in Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK., Palmer S; Dxcover Ltd., Glasgow G33 1AP, UK; WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1XL, UK., Nørøxe DS; Danish Comprehensive Cancer Center Brain Tumor Centre, 2100 Copenhagen, Denmark; Department of Oncology, University Hospital of Copenhagen, 2100 Copenhagen, Denmark., Filippou PS; School of Health & Life Sciences, Teesside University, Middlesbrough TS1 3BX, UK; National Horizons Centre, Teesside University, Darlington DL1 1HG, UK; School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece., Renaut J; Bioinformatics Laboratory, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK., Lazarus A; Dxcover Ltd., Glasgow G33 1AP, UK., Antoniou G; Dxcover Ltd., Glasgow G33 1AP, UK., Samuels M; International Oncology Institute, The First Affiliated Hospital of Zhejiang Chinese Medical University, Oncology Department of the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, China; Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK., Vella V; Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK., Filippopoulou C; International Oncology Institute, The First Affiliated Hospital of Zhejiang Chinese Medical University, Oncology Department of the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, China., Jones W; Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK., Jung J; Department of Neurosurgery, Kings College Hospital NHS Foundation Trust, London SE5 9RS, UK., Li X; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China., Ji N; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China., Zhang Y; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China., Azam A; Department of Neurosurgery, University Hospital of Copenhagen, 2100 Copenhagen, Denmark., Skjoeth-Rasmussen J; Department of Neurosurgery, University Hospital of Copenhagen, 2100 Copenhagen, Denmark., Lassen U; Danish Comprehensive Cancer Center Brain Tumor Centre, 2100 Copenhagen, Denmark; Department of Oncology, University Hospital of Copenhagen, 2100 Copenhagen, Denmark., Saraiva A; Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand., Taha A; Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand., Slatter T; Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand., Jones G; Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand., Katare R; Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand., Butler HJ; Dxcover Ltd., Glasgow G33 1AP, UK., Baker MJ; Dxcover Ltd., Glasgow G33 1AP, UK; School of Medicine, University of Central Lancashire, Preston PR1 7BH, UK., Hadjidemetriou M; NanoOmics Lab, Centre for Nanotechnology in Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK., Gilbert D; Sussex Cancer Centre, University Hospitals Sussex NHS Foundation Trust, Brighton BN2 5BE, UK; MRC Clinical Trials Unit, University College London, London WC1V 6LJ, UK., Towler B; Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK., Ashkan K; Department of Neurosurgery, Kings College Hospital NHS Foundation Trust, London SE5 9RS, UK., Critchley G; Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand; Department of Neurosurgery, University Hospitals Sussex NHS Foundation Trust, Brighton BN2 5BE, UK., Pearl FMG; Bioinformatics Laboratory, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK., Giamas G; International Oncology Institute, The First Affiliated Hospital of Zhejiang Chinese Medical University, Oncology Department of the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, China; Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK. Electronic address: georgios.giamas@zcmu.edu.cn.
Source: Cell reports. Medicine [Cell Rep Med] 2026 May 19; Vol. 7 (5), pp. 102744. Date of Electronic Publication: 2026 Apr 17.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2666-3791
DOI:10.1016/j.xcrm.2026.102744