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Exosomal microRNA-4800-3p in portal vein blood promotes liver metastasis in pancreatic cancer by targeting PLAA.

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Title: Exosomal microRNA-4800-3p in portal vein blood promotes liver metastasis in pancreatic cancer by targeting PLAA.
Authors: Miyahara S; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan., Takahashi H; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan. htakahashi8@gesurg.med.osaka-u.ac.jp., Tomimaru Y; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan., Kobayashi S; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan., Tahara S; Department of Pathology, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, 565-0871, Osaka, Japan., Sasaki K; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan., Hasegawa S; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan., Iwagami Y; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan., Yamada D; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan., Akita H; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan., Asaoka T; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan., Noda T; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan., Wada H; Department of Gastroenterological Surgery, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan., Shimizu J; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan., Morii E; Department of Pathology, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, 565-0871, Osaka, Japan., Doki Y; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan., Eguchi H; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.
Source: Scientific reports [Sci Rep] 2026 Apr 19; Vol. 16 (1). Date of Electronic Publication: 2026 Apr 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE; In Process
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  Data: Exosomal microRNA-4800-3p in portal vein blood promotes liver metastasis in pancreatic cancer by targeting PLAA.
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  Data: <searchLink fieldCode="AU" term="%22Miyahara+S%22">Miyahara S</searchLink>; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Takahashi+H%22">Takahashi H</searchLink>; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan. htakahashi8@gesurg.med.osaka-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Tomimaru+Y%22">Tomimaru Y</searchLink>; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Kobayashi+S%22">Kobayashi S</searchLink>; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Tahara+S%22">Tahara S</searchLink>; Department of Pathology, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, 565-0871, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Sasaki+K%22">Sasaki K</searchLink>; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Hasegawa+S%22">Hasegawa S</searchLink>; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Iwagami+Y%22">Iwagami Y</searchLink>; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Yamada+D%22">Yamada D</searchLink>; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Akita+H%22">Akita H</searchLink>; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Asaoka+T%22">Asaoka T</searchLink>; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Noda+T%22">Noda T</searchLink>; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Wada+H%22">Wada H</searchLink>; Department of Gastroenterological Surgery, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan.<br /><searchLink fieldCode="AU" term="%22Shimizu+J%22">Shimizu J</searchLink>; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Morii+E%22">Morii E</searchLink>; Department of Pathology, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, 565-0871, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Doki+Y%22">Doki Y</searchLink>; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Eguchi+H%22">Eguchi H</searchLink>; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.
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