Discovery of Naphthyridinone Derivatives as Selective PKMYT1/WEE1 Dual Inhibitors for Cancer Therapy.

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Bibliographic Details
Title: Discovery of Naphthyridinone Derivatives as Selective PKMYT1/WEE1 Dual Inhibitors for Cancer Therapy.
Authors: Chen B; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China., Liu X; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China., Xu J; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China., Zhao D; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China., Tang Y; Lead Discovery, China Innovation Center of Roche, Shanghai 201203, China., Xu Z; Lead Discovery, China Innovation Center of Roche, Shanghai 201203, China., Yang J; Lead Discovery, China Innovation Center of Roche, Shanghai 201203, China., Li C; Lead Discovery, China Innovation Center of Roche, Shanghai 201203, China., Chen S; Lead Discovery, China Innovation Center of Roche, Shanghai 201203, China., Zhu S; Oncology Discovery, China Innovation Center of Roche, Shanghai 201203, China., Wang S; Oncology Discovery, China Innovation Center of Roche, Shanghai 201203, China., Yao X; Oncology Discovery, China Innovation Center of Roche, Shanghai 201203, China., Yan Z; Oncology Discovery, China Innovation Center of Roche, Shanghai 201203, China., Weng M; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China., Wang P; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China., Ma Y; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China., Wang X; AI, Data and Digital, China Innovation Center of Roche, Shanghai 201203, China., Chen WK; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China., Tu Y; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China., Qiu H; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China., Yang J; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China., Jiang T; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China., Ji Y; Technical Research and Development, China Innovation Center of Roche, Shanghai 201203, China., Shen HC; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China., Zhu W; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China., Tan X; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China., Wu J; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China.
Source: Journal of medicinal chemistry [J Med Chem] 2026 May 14; Vol. 69 (9), pp. 10380-10397. Date of Electronic Publication: 2026 Apr 20.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.5c03521