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Discovery of Naphthyridinone Derivatives as Selective PKMYT1/WEE1 Dual Inhibitors for Cancer Therapy.

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Title: Discovery of Naphthyridinone Derivatives as Selective PKMYT1/WEE1 Dual Inhibitors for Cancer Therapy.
Authors: Chen B; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China., Liu X; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China., Xu J; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China., Zhao D; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China., Tang Y; Lead Discovery, China Innovation Center of Roche, Shanghai 201203, China., Xu Z; Lead Discovery, China Innovation Center of Roche, Shanghai 201203, China., Yang J; Lead Discovery, China Innovation Center of Roche, Shanghai 201203, China., Li C; Lead Discovery, China Innovation Center of Roche, Shanghai 201203, China., Chen S; Lead Discovery, China Innovation Center of Roche, Shanghai 201203, China., Zhu S; Oncology Discovery, China Innovation Center of Roche, Shanghai 201203, China., Wang S; Oncology Discovery, China Innovation Center of Roche, Shanghai 201203, China., Yao X; Oncology Discovery, China Innovation Center of Roche, Shanghai 201203, China., Yan Z; Oncology Discovery, China Innovation Center of Roche, Shanghai 201203, China., Weng M; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China., Wang P; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China., Ma Y; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China., Wang X; AI, Data and Digital, China Innovation Center of Roche, Shanghai 201203, China., Chen WK; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China., Tu Y; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China., Qiu H; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China., Yang J; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China., Jiang T; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China., Ji Y; Technical Research and Development, China Innovation Center of Roche, Shanghai 201203, China., Shen HC; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China., Zhu W; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China., Tan X; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China., Wu J; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China.
Source: Journal of medicinal chemistry [J Med Chem] 2026 May 14; Vol. 69 (9), pp. 10380-10397. Date of Electronic Publication: 2026 Apr 20.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
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  Data: Discovery of Naphthyridinone Derivatives as Selective PKMYT1/WEE1 Dual Inhibitors for Cancer Therapy.
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  Data: <searchLink fieldCode="AU" term="%22Chen+B%22">Chen B</searchLink>; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhao+D%22">Zhao D</searchLink>; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Tang+Y%22">Tang Y</searchLink>; Lead Discovery, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Xu+Z%22">Xu Z</searchLink>; Lead Discovery, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Lead Discovery, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Lead Discovery, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; Lead Discovery, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhu+S%22">Zhu S</searchLink>; Oncology Discovery, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Oncology Discovery, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Yao+X%22">Yao X</searchLink>; Oncology Discovery, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Yan+Z%22">Yan Z</searchLink>; Oncology Discovery, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Weng+M%22">Weng M</searchLink>; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Wang+P%22">Wang P</searchLink>; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Ma+Y%22">Ma Y</searchLink>; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; AI, Data and Digital, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Chen+WK%22">Chen WK</searchLink>; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Tu+Y%22">Tu Y</searchLink>; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Qiu+H%22">Qiu H</searchLink>; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Jiang+T%22">Jiang T</searchLink>; Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Ji+Y%22">Ji Y</searchLink>; Technical Research and Development, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Shen+HC%22">Shen HC</searchLink>; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhu+W%22">Zhu W</searchLink>; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Tan+X%22">Tan X</searchLink>; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Medicinal Chemistry, China Innovation Center of Roche, Shanghai 201203, China.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2026 May 14; Vol. 69 (9), pp. 10380-10397. <i>Date of Electronic Publication: </i>2026 Apr 20.
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        Value: 10.1021/acs.jmedchem.5c03521
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        Text: English
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              Text: 2026 May 14
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