Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell-Type-Specific TGFβ Modulators.

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Title: Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell-Type-Specific TGFβ Modulators.
Authors: van Dinther M; Oncode Institute and Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands., Schwartze T; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Zhang J; Oncode Institute and Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands., Fan K; Oncode Institute and Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands., van der Zon G; Oncode Institute and Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands., Power L; Centre for Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, UK., Hinck CS; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Ciancia C; Centre for Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, UK., Mukundan A; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Gonzalez-Prieto R; Andalusian Center for Molecular Biology and Regenerative Medicine, Universidad de Sevilla - CSIC - Universidad Pablo de Olavide, Sevilla, Spain.; Department of Cell Biology, Faculty of Biology, University of Sevilla, Sevilla, Spain., van Veelen P; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands., Maizels RM; Centre for Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, UK., Hinck AP; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Ten Dijke P; Oncode Institute and Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.
Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2026 Apr 20, pp. e75322. Date of Electronic Publication: 2026 Apr 20.
Publication Type: Journal Article
Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2198-3844
DOI:10.1002/advs.75322