Intranasal replicating adenovirus type 4-vectored SARS-CoV-2 vaccines induce durable and efficacious responses in preclinical testing.

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Title: Intranasal replicating adenovirus type 4-vectored SARS-CoV-2 vaccines induce durable and efficacious responses in preclinical testing.
Authors: Kim B; HIV-Specific Immunity, Bethesda, MD 20892, USA., Roenicke R; HIV-Specific Immunity, Bethesda, MD 20892, USA., Roeder PM; HIV-Specific Immunity, Bethesda, MD 20892, USA., Steinberg I; HIV-Specific Immunity, Bethesda, MD 20892, USA., Patamawenu A; HIV-Specific Immunity, Bethesda, MD 20892, USA., Harrison M; HIV-Specific Immunity, Bethesda, MD 20892, USA., Veer FV; HIV-Specific Immunity, Bethesda, MD 20892, USA., Koory E; HIV-Specific Immunity, Bethesda, MD 20892, USA., Xie J; HIV-Specific Immunity, Bethesda, MD 20892, USA., Shofner T; HIV-Specific Immunity, Bethesda, MD 20892, USA., Matsuda K; HIV-Specific Immunity, Bethesda, MD 20892, USA., Wettstein E; HIV-Specific Immunity, Bethesda, MD 20892, USA., Ober E; HIV-Specific Immunity, Bethesda, MD 20892, USA., Cooney C; HIV-Specific Immunity, Bethesda, MD 20892, USA., Kim T; HIV-Specific Immunity, Bethesda, MD 20892, USA., Webber JD; HIV-Specific Immunity, Bethesda, MD 20892, USA., Meeks T; HIV-Specific Immunity, Bethesda, MD 20892, USA., Park C; B-Cell Molecular Immunology Sections of the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Burdette T; SARS-CoV-2 Virology Core, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Georgia S; SARS-CoV-2 Virology Core, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Readler JM; Medical Virology Section of the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Vostal AC; Medical Virology Section of the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Hostal A; Medical Virology Section of the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Cohen JI; Medical Virology Section of the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Gagne M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Ziff Z; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Richard K; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Burnett MR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Maule E; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Callier V; Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA., Liang J; Office of Biostatistics Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Kovacikova G; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA., Souter SC; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA., Weiner JA; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA., Douek D; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Ackerman ME; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.; Department of Microbiology and Immunology, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA., Wright PF; Department of Pediatrics, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03766, USA., Johnson RF; SARS-CoV-2 Virology Core, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Connors M; HIV-Specific Immunity, Bethesda, MD 20892, USA.
Source: IScience [iScience] 2026 Mar 20; Vol. 29 (4), pp. 115433. Date of Electronic Publication: 2026 Mar 20 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2589-0042
DOI:10.1016/j.isci.2026.115433