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Intranasal replicating adenovirus type 4-vectored SARS-CoV-2 vaccines induce durable and efficacious responses in preclinical testing.

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Title: Intranasal replicating adenovirus type 4-vectored SARS-CoV-2 vaccines induce durable and efficacious responses in preclinical testing.
Authors: Kim B; HIV-Specific Immunity, Bethesda, MD 20892, USA., Roenicke R; HIV-Specific Immunity, Bethesda, MD 20892, USA., Roeder PM; HIV-Specific Immunity, Bethesda, MD 20892, USA., Steinberg I; HIV-Specific Immunity, Bethesda, MD 20892, USA., Patamawenu A; HIV-Specific Immunity, Bethesda, MD 20892, USA., Harrison M; HIV-Specific Immunity, Bethesda, MD 20892, USA., Veer FV; HIV-Specific Immunity, Bethesda, MD 20892, USA., Koory E; HIV-Specific Immunity, Bethesda, MD 20892, USA., Xie J; HIV-Specific Immunity, Bethesda, MD 20892, USA., Shofner T; HIV-Specific Immunity, Bethesda, MD 20892, USA., Matsuda K; HIV-Specific Immunity, Bethesda, MD 20892, USA., Wettstein E; HIV-Specific Immunity, Bethesda, MD 20892, USA., Ober E; HIV-Specific Immunity, Bethesda, MD 20892, USA., Cooney C; HIV-Specific Immunity, Bethesda, MD 20892, USA., Kim T; HIV-Specific Immunity, Bethesda, MD 20892, USA., Webber JD; HIV-Specific Immunity, Bethesda, MD 20892, USA., Meeks T; HIV-Specific Immunity, Bethesda, MD 20892, USA., Park C; B-Cell Molecular Immunology Sections of the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Burdette T; SARS-CoV-2 Virology Core, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Georgia S; SARS-CoV-2 Virology Core, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Readler JM; Medical Virology Section of the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Vostal AC; Medical Virology Section of the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Hostal A; Medical Virology Section of the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Cohen JI; Medical Virology Section of the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Gagne M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Ziff Z; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Richard K; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Burnett MR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Maule E; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Callier V; Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA., Liang J; Office of Biostatistics Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Kovacikova G; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA., Souter SC; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA., Weiner JA; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA., Douek D; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Ackerman ME; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.; Department of Microbiology and Immunology, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA., Wright PF; Department of Pediatrics, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03766, USA., Johnson RF; SARS-CoV-2 Virology Core, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Connors M; HIV-Specific Immunity, Bethesda, MD 20892, USA.
Source: IScience [iScience] 2026 Mar 20; Vol. 29 (4), pp. 115433. Date of Electronic Publication: 2026 Mar 20 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
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  Data: Intranasal replicating adenovirus type 4-vectored SARS-CoV-2 vaccines induce durable and efficacious responses in preclinical testing.
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  Data: <searchLink fieldCode="AU" term="%22Kim+B%22">Kim B</searchLink>; HIV-Specific Immunity, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Roenicke+R%22">Roenicke R</searchLink>; HIV-Specific Immunity, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Roeder+PM%22">Roeder PM</searchLink>; HIV-Specific Immunity, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Steinberg+I%22">Steinberg I</searchLink>; HIV-Specific Immunity, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Patamawenu+A%22">Patamawenu A</searchLink>; HIV-Specific Immunity, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Harrison+M%22">Harrison M</searchLink>; HIV-Specific Immunity, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Veer+FV%22">Veer FV</searchLink>; HIV-Specific Immunity, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Koory+E%22">Koory E</searchLink>; HIV-Specific Immunity, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Xie+J%22">Xie J</searchLink>; HIV-Specific Immunity, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Shofner+T%22">Shofner T</searchLink>; HIV-Specific Immunity, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Matsuda+K%22">Matsuda K</searchLink>; HIV-Specific Immunity, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Wettstein+E%22">Wettstein E</searchLink>; HIV-Specific Immunity, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Ober+E%22">Ober E</searchLink>; HIV-Specific Immunity, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Cooney+C%22">Cooney C</searchLink>; HIV-Specific Immunity, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Kim+T%22">Kim T</searchLink>; HIV-Specific Immunity, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Webber+JD%22">Webber JD</searchLink>; HIV-Specific Immunity, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Meeks+T%22">Meeks T</searchLink>; 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Medical Virology Section of the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Hostal+A%22">Hostal A</searchLink>; Medical Virology Section of the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Cohen+JI%22">Cohen JI</searchLink>; Medical Virology Section of the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Gagne+M%22">Gagne M</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Ziff+Z%22">Ziff Z</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Richard+K%22">Richard K</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Burnett+MR%22">Burnett MR</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Maule+E%22">Maule E</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Callier+V%22">Callier V</searchLink>; Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.<br /><searchLink fieldCode="AU" term="%22Liang+J%22">Liang J</searchLink>; Office of Biostatistics Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Kovacikova+G%22">Kovacikova G</searchLink>; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.<br /><searchLink fieldCode="AU" term="%22Souter+SC%22">Souter SC</searchLink>; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.<br /><searchLink fieldCode="AU" term="%22Weiner+JA%22">Weiner JA</searchLink>; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.<br /><searchLink fieldCode="AU" term="%22Douek+D%22">Douek D</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Ackerman+ME%22">Ackerman ME</searchLink>; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.; Department of Microbiology and Immunology, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA.<br /><searchLink fieldCode="AU" term="%22Wright+PF%22">Wright PF</searchLink>; Department of Pediatrics, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03766, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+RF%22">Johnson RF</searchLink>; SARS-CoV-2 Virology Core, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Connors+M%22">Connors M</searchLink>; HIV-Specific Immunity, Bethesda, MD 20892, USA.
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