Cerebral Oximetry in Extremely Preterm Infants: 2-Year Follow-Up of the SafeBoosC-III Randomized Clinical Trial.

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Title: Cerebral Oximetry in Extremely Preterm Infants: 2-Year Follow-Up of the SafeBoosC-III Randomized Clinical Trial.
Authors: Rasmussen MIS; Department of Neonatology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Hansen ML; Department of Neonatology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Pellicer A; Department of Neonatology, La Paz University Hospital, Madrid, Spain.; Hospital La Paz Institute for Health Research-IdiPAZ, Madrid, Spain., Hyttel-Sørensen S; Department of Intensive Care, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Ergenekon E; Division of Newborn Medicine, Gazi University Hospital, Ankara, Turkey., Szczapa T; 2nd Department of Neonatology, Neonatal Biophysical Monitoring and Cardiopulmonary Therapies Research Unit, Chair of Neonatology, Poznan University of Medical Sciences, Poznan, Poland., Hagmann C; Pediatric Intensive Care and Neonatology, Children's University Hospital of Zurich, Zurich, Switzerland., Naulaers G; Department of Development and Regeneration, KU Leuven, Leuven, Belgium., Mintzer J; Department of Pediatrics, Division of Newborn Medicine, Mountainside Medical Center, Montclair, New Jersey., Fumagalli M; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy., Dimitriou G; NICU, Department of Pediatrics, Patras Medical School, Patras, Greece., Dempsey E; Infant Centre and Department of Paediatrics and Child Health, University College Cork, Cork, Ireland., Tkaczyk J; Department of Neonatology, University Hospital Motol, Prague, Czech Republic., Fredly S; Department of Neonatology, Oslo University Hospital, Oslo, Norway., Heuchan AM; Department of Neonatal Medicine, Royal Hospital for Children, Glasgow, United Kingdom., Pichler G; Department of Pediatrics, Medical University of Graz, Graz, Austria.; Research Unit for Neonatal Micro- and Macrocirculation, Medical University of Graz, Graz, Austria., Fuchs H; Division of Neonatology and Pediatric Intensive Care Medicine, Center for Pediatrics and Adolescents Medicine, Medical Center - University of Freiburg, Freiburg, Germany.; Faculty of Medicine, University of Freiburg, Freiburg, Germany., Nesargi S; Department of Neonatology, St John's Medical College, Bangalore, India., Hahn GH; Department of Neonatology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Piris-Borregas S; Neonatology Department, 12 de Octubre University Hospital, Madrid, Spain., Širc J; The Institute for the Care of Mother and Child, Prague, Czech Republic.; Third Faculty of Medicine, Charles University, Prague, Czech Republic., Alsina-Casanova M; Department of Neonatology, Hospital Clínic Barcelona, BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine, Barcelona, Spain., Stocker M; Intensive Care Unit, Children's Hospital Lucerne, Lucerne, Switzerland.; Faculty of Medicine and Medical Science, University of Lucerne, Lucerne, Switzerland., Ozkan H; Department of Neonatology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey., Sarafidis K; 1st Department of Neonatology, Aristotle University of Thessaloniki, Ippokrateion General Hospital of Thessaloniki, Greece., Kraus NJ; Division of Neonatology, Department of Pediatrics, Loma Linda University Children's Hospital, Loma Linda, California., Karen T; Intensive Care Unit, Children's Hospital Lucerne, Lucerne, Switzerland.; Department of Neonatology, University Hospital Zurich, Zurich, Switzerland., Rzepecka-Weglarz B; Department of Neonatology, Centrum Medyczne 'Ujastek' Sp. z o.o., Krakow, Poland., Oguz SS; Department of Neonatology, NICU, University of Health Sciences, Ankara City Hospital, Ankara, Turkey., Thewissen L; Department of Development and Regeneration, KU Leuven, Leuven, Belgium., Arruza L; Department of Neonatology, Hospital Clinico San Carlos-IdISSC, Madrid, Spain., Memisoglu AC; Division of Neonatology, Department of Pediatrics, Marmara University Research and Education Hospital, Marmara University, School of Medicine, Istanbul, Turkey., Del Rio Florentino R; Department of Neonatology, Hospital Sant Joan de Deu, Barcelona, Spain., Baserga M; Division of Neonatology, University of Utah Hospital, Salt Lake City., Maton P; Service de Néonatologie, Clinique CHC Montlégia-Liège-Belgium, Belgium., Schneider J; Clinic of Neonatology, Department of Women, Mother and Child, University Hospital Center, Vaud, Switzerland.; University of Lausanne, Vaud, Switzerland., de Las Cuevas MI; Neonatal Unit, Donostia University Hospital-IIS Biogipuzkoa, Basque Country, Spain., Hedegaard SS; Department of Pediatrics and Adolescent Medicine, Gødstrup Hospital, Denmark., Zafra P; Neonatal Intensive Care Unit, Puerta del Mar University Hospital, Cádiz, Spain., Bender L; Department of Neonatology, Aalborg University Hospital, Aalborg, Denmark., Farquharson S; Department of Neonatal Medicine, Royal Hospital for Children, Glasgow, United Kingdom., Ochoda-Mazur A; Neonatology Clinic, Jagiellonian University Medical College, Kraków, Poland., Lecart C; Department of Neonatology, GHdC Charleroi, Belgium., El-Khuffash A; Department of Paediatrics, School of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., Chathasaigh CN; National Maternity Hospital, Dublin, Ireland., Miletin J; The Coombe Hospital, Dublin, Ireland.; University College Dublin, Dublin, Ireland.; 2nd Faculty of Medicine, Charles University, Prague, Czech Republic., Papathoma E; Neonatal Intensive Care Unit, Alexandra University and State Hospital, Athens, Greece., Vesoulis Z; Division of Newborn Medicine, Department of Pediatrics, Washington University School of Medicine in St Louis, St Louis, Missouri., Serrao F; Unità Operativa Complessa di Neonatologia, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Cornette L; Department of Neonatology, AZ St-Jan Bruges, Bruges, Belgium., Yasa B; Basaksehir Cam and Sakura City Hospital, Basaksehir, Turkey.; Department of Neonatology, Kanuni Sultan Suleyman Training and Research Hospital, Küçükçekmece/İstanbul, Turkey., Klamer A; Department of Pediatrics, Odense University Hospital, Odense, Denmark., Barcos-Munoz F; Division of Neonatology and Pediatric Intensive Care, Children's University Hospital of Geneva and University of Geneva, Geneva, Switzerland., Boetti T; SC Neonatologia, Osp. S.Anna - Città della Salute e della Scienza di Torino, Turin, Italy., Cetinkaya M; Basaksehir Cam and Sakura City Hospital, Basaksehir, Turkey.; Department of Neonatology, Kanuni Sultan Suleyman Training and Research Hospital, Küçükçekmece/İstanbul, Turkey., Montasser M; Neonatology Department, University Hospital Wishaw, Wishaw, Scotland, United Kingdom., Hatzidaki E; Department of Neonatology & NICU, University Hospital of Heraklion, Crete, Greece., Bokiniec R; Department of Neonatology and Neonatal Intensive Care, Medical University of Warsaw, Warsaw, Poland., Marciniak S; Neonatal Unit, Specialist Hospital No. 2, Bytom, Poland., Chalak L; Division of Pediatrics-Neonatal-Perinatal, UT Southwestern, Dallas, Texas., Rao SA; Department of Neonatology, St John's Medical College, Bangalore, India., Sadowska-Krawczenko I; Department of Neonatology, Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun, Bydgoszcz, Poland., Serrano-Viñuales I; Neonatology Division, Miguel Servet University Hospital, Zaragoza, Spain., Krolak-Olejnik B; Department of Neonatology, Wroclaw Medical University, Wroclaw, Poland., Plomgaard AM; Department of Pediatrics, Hvidovre University Hospital, Hvidovre, Denmark., Hansen BM; Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Hilleroed, Denmark., Olsen MH; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Neuroanaesthesiology, Neuroscience Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Gluud C; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Jakobsen JC; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Greisen G; Department of Neonatology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Corporate Authors: SafeBoosC-III Follow-Up Writing Group for the SafeBoosC-III Follow-Up Collaborator Group
Source: JAMA pediatrics [JAMA Pediatr] 2026 Jun 01; Vol. 180 (6), pp. 619-627.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase III
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589544 Publication Model: Print Cited Medium: Internet ISSN: 2168-6211 (Electronic) Linking ISSN: 21686203 NLM ISO Abbreviation: JAMA Pediatr Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2168-6211
DOI:10.1001/jamapediatrics.2026.1066