Elevated plasma IgG is associated with improved treatment response and survival in advanced non‑small cell lung cancer patients treated with anti‑PD‑1 therapy.

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Title: Elevated plasma IgG is associated with improved treatment response and survival in advanced non‑small cell lung cancer patients treated with anti‑PD‑1 therapy.
Authors: Ohkuma R; Department of Oncology, Graduate School of Medicine, Showa Medical University, Tokyo, Japan.; Showa Medical University Comprehensive Cancer Information Center, Showa Medical University, Tokyo, Japan.; Department of Clinical Diagnostic Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan., Onishi N; Department of Clinical Diagnostic Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan., Watanabe M; Department of Clinical Diagnostic Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan., Jin J; Department of Clinical Diagnostic Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan., Ariizumi H; Department of Oncology, Graduate School of Medicine, Showa Medical University, Tokyo, Japan., Shimokawa M; Department of Oncology, Graduate School of Medicine, Showa Medical University, Tokyo, Japan., Ikeda G; Department of Oncology, Graduate School of Medicine, Showa Medical University, Tokyo, Japan., Ishiguro T; Department of Oncology, Graduate School of Medicine, Showa Medical University, Tokyo, Japan., Suzuki R; Department of Oncology, Graduate School of Medicine, Showa Medical University, Tokyo, Japan.; Department of Pharmacology, Graduate School of Medicine, Showa Medical University, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan., Tsurui T; Department of Oncology, Graduate School of Medicine, Showa Medical University, Tokyo, Japan.; Department of Pharmacology, Graduate School of Medicine, Showa Medical University, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan., Kubota Y; Department of Oncology, Graduate School of Medicine, Showa Medical University, Tokyo, Japan., Yoshimura K; Department of Oncology, Graduate School of Medicine, Showa Medical University, Tokyo, Japan.; Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan., Kobayashi S; Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan., Tsunoda T; Department of Oncology, Graduate School of Medicine, Showa Medical University, Tokyo, Japan.; Showa Medical University Comprehensive Cancer Information Center, Showa Medical University, Tokyo, Japan., Horiike A; Department of Oncology, Graduate School of Medicine, Showa Medical University, Tokyo, Japan., Wada S; Department of Oncology, Graduate School of Medicine, Showa Medical University, Tokyo, Japan. st-wada@med.showa-u.ac.jp.; Department of Clinical Diagnostic Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan. st-wada@med.showa-u.ac.jp.; Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan. st-wada@med.showa-u.ac.jp.; Department of Pharmacology, Graduate School of Medicine, Showa Medical University, Tokyo, Japan. st-wada@med.showa-u.ac.jp.
Source: Scientific reports [Sci Rep] 2026 Apr 20; Vol. 16 (1). Date of Electronic Publication: 2026 Apr 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
Description
ISSN:2045-2322
DOI:10.1038/s41598-026-46923-x