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On-treatment viral factors affect subsequent hepatitis B surface antigen seroclearance in patients treated with nucleos(t)ide analogs for > 10 years.

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Title: On-treatment viral factors affect subsequent hepatitis B surface antigen seroclearance in patients treated with nucleos(t)ide analogs for > 10 years.
Authors: Hosaka T; Department of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Suita, Japan.; Department of Hepatology, Toranomon Hospital, Tokyo, Japan., Hikita H; Department of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Suita, Japan. hikita@gh.med.osaka-u.ac.jp., Tahata Y; Department of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Suita, Japan., Yamada R; Department of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Suita, Japan., Murai K; Department of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Suita, Japan., Miyazaki M; Department of Gastroenterology, Osaka Keisatsu Hospital, Osaka, Japan., Ishida H; Department of Gastroenterology and Hepatology, Ikeda Municipal Hospital, Ikeda, Japan., Hosui A; Department of Gastroenterology and Hepatology, Osaka Rosai Hospital, Sakai, Japan., Sakamori R; Department of Gastroenterology and Hepatology, NHO Osaka National Hospital, Osaka, Japan., Tatsumi N; Department of Gastroenterology and Hepatology, Japan Community Healthcare Organization Osaka Hospital, Osaka, Japan., Doi Y; Department of Gastroenterology and Hepatology, Otemae Hospital, Osaka, Japan., Ohkawa K; Department of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka, Japan., Egawa S; Department of Gastroenterology and Hepatology, Kinki Central Hospital of Mutual Aid Association of Public School Teachers, Itami, Japan., Nawa T; Department of Gastroenterology and Hepatology, Higashiosaka City Medical Center, Osaka, Japan., Nozaki Y; Department of Gastroenterology and Hepatology, Kansai Rosai Hospital, Amagasaki, Japan., Imanaka K; Department of Gastroenterology and Hepatology, Itami City Hospital, Itami, Japan., Nakahara M; Department of Gastroenterology and Hepatology, Minoh City Hospital, Minoh, Japan., Sakakibara M; Department of Gastroenterology and Hepatology, Yao Municipal Hospital, Yao, Japan., Yakushijin T; Department of Gastroenterology and Hepatology, Osaka General Medical Center, Osaka, Japan., Yoshida Y; Department of Gastroenterology and Hepatology, Suita Municipal Hospital, Suita, Japan., Ogawa H; Department of Gastroenterology, Nishinomiya Municipal Central Hospital, Nishinomiya, Japan., Usui T; Department of Gastroenterology and Hepatology, Ashiya Municipal Hospital, Ashiya, Japan., Matsumoto K; Department of Gastroenterology and Hepatology, Toyonaka Municipal Hospital, Toyonaka, Japan., Maesaka K; Department of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Suita, Japan., Shirai K; Department of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Suita, Japan., Makino Y; Department of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Suita, Japan., Saito Y; Department of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Suita, Japan., Kodama T; Department of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Suita, Japan., Takehara T; Department of Gastroenterology and Hepatology, Kansai Rosai Hospital, Amagasaki, Japan.
Source: Journal of gastroenterology [J Gastroenterol] 2026 Jul; Vol. 61 (7), pp. 990-1002. Date of Electronic Publication: 2026 Apr 21.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Country of Publication: Japan NLM ID: 9430794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-5922 (Electronic) Linking ISSN: 09441174 NLM ISO Abbreviation: J Gastroenterol Subsets: MEDLINE
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  Data: On-treatment viral factors affect subsequent hepatitis B surface antigen seroclearance in patients treated with nucleos(t)ide analogs for > 10 years.
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  Data: <searchLink fieldCode="AU" term="%22Hosaka+T%22">Hosaka T</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Suita, Japan.; Department of Hepatology, Toranomon Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hikita+H%22">Hikita H</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Suita, Japan. hikita@gh.med.osaka-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Tahata+Y%22">Tahata Y</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Yamada+R%22">Yamada R</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Murai+K%22">Murai K</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Miyazaki+M%22">Miyazaki M</searchLink>; Department of Gastroenterology, Osaka Keisatsu Hospital, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Ishida+H%22">Ishida H</searchLink>; Department of Gastroenterology and Hepatology, Ikeda Municipal Hospital, Ikeda, Japan.<br /><searchLink fieldCode="AU" term="%22Hosui+A%22">Hosui A</searchLink>; Department of Gastroenterology and Hepatology, Osaka Rosai Hospital, Sakai, Japan.<br /><searchLink fieldCode="AU" term="%22Sakamori+R%22">Sakamori R</searchLink>; Department of Gastroenterology and Hepatology, NHO Osaka National Hospital, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Tatsumi+N%22">Tatsumi N</searchLink>; Department of Gastroenterology and Hepatology, Japan Community Healthcare Organization Osaka Hospital, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Doi+Y%22">Doi Y</searchLink>; Department of Gastroenterology and Hepatology, Otemae Hospital, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Ohkawa+K%22">Ohkawa K</searchLink>; Department of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Egawa+S%22">Egawa S</searchLink>; Department of Gastroenterology and Hepatology, Kinki Central Hospital of Mutual Aid Association of Public School Teachers, Itami, Japan.<br /><searchLink fieldCode="AU" term="%22Nawa+T%22">Nawa T</searchLink>; Department of Gastroenterology and Hepatology, Higashiosaka City Medical Center, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Nozaki+Y%22">Nozaki Y</searchLink>; Department of Gastroenterology and Hepatology, Kansai Rosai Hospital, Amagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Imanaka+K%22">Imanaka K</searchLink>; Department of Gastroenterology and Hepatology, Itami City Hospital, Itami, Japan.<br /><searchLink fieldCode="AU" term="%22Nakahara+M%22">Nakahara M</searchLink>; Department of Gastroenterology and Hepatology, Minoh City Hospital, Minoh, Japan.<br /><searchLink fieldCode="AU" term="%22Sakakibara+M%22">Sakakibara M</searchLink>; Department of Gastroenterology and Hepatology, Yao Municipal Hospital, Yao, Japan.<br /><searchLink fieldCode="AU" term="%22Yakushijin+T%22">Yakushijin T</searchLink>; Department of Gastroenterology and Hepatology, Osaka General Medical Center, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Yoshida+Y%22">Yoshida Y</searchLink>; Department of Gastroenterology and Hepatology, Suita Municipal Hospital, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Ogawa+H%22">Ogawa H</searchLink>; Department of Gastroenterology, Nishinomiya Municipal Central Hospital, Nishinomiya, Japan.<br /><searchLink fieldCode="AU" term="%22Usui+T%22">Usui T</searchLink>; Department of Gastroenterology and Hepatology, Ashiya Municipal Hospital, Ashiya, Japan.<br /><searchLink fieldCode="AU" term="%22Matsumoto+K%22">Matsumoto K</searchLink>; Department of Gastroenterology and Hepatology, Toyonaka Municipal Hospital, Toyonaka, Japan.<br /><searchLink fieldCode="AU" term="%22Maesaka+K%22">Maesaka K</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Shirai+K%22">Shirai K</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Makino+Y%22">Makino Y</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Saito+Y%22">Saito Y</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Kodama+T%22">Kodama T</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Takehara+T%22">Takehara T</searchLink>; Department of Gastroenterology and Hepatology, Kansai Rosai Hospital, Amagasaki, Japan.
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  Data: <searchLink fieldCode="JN" term="%229430794%22">Journal of gastroenterology</searchLink> [J Gastroenterol] 2026 Jul; Vol. 61 (7), pp. 990-1002. <i>Date of Electronic Publication: </i>2026 Apr 21.
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