TGF-β/SMAD4/14-3-3σ/TFEB axis promotes mesenchymal-epithelial transition and inhibits autophagy in colorectal cancer.

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Title: TGF-β/SMAD4/14-3-3σ/TFEB axis promotes mesenchymal-epithelial transition and inhibits autophagy in colorectal cancer.
Authors: Chen X; Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-University München, Thalkirchner Strasse 36, D-80337, Munich, Germany., Winter M; Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-University München, Thalkirchner Strasse 36, D-80337, Munich, Germany., Rokavec M; Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-University München, Thalkirchner Strasse 36, D-80337, Munich, Germany., König J; Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-University München, Thalkirchner Strasse 36, D-80337, Munich, Germany., Hermeking H; Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-University München, Thalkirchner Strasse 36, D-80337, Munich, Germany. heiko.hermeking@med.uni-muenchen.de.; German Cancer Consortium (DKTK), Partner Site Munich, D-80336, Munich, Germany. heiko.hermeking@med.uni-muenchen.de.; German Cancer Research Center (DKFZ), D-69210, Heidelberg, Germany. heiko.hermeking@med.uni-muenchen.de.
Source: Cell death & disease [Cell Death Dis] 2026 Apr 21; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-4889
DOI:10.1038/s41419-026-08733-x