HDAC8 inhibition targets STAT3-MYC axis and synergizes with Venetoclax in KMT2A-rearranged acute myeloid leukemia.

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Title: HDAC8 inhibition targets STAT3-MYC axis and synergizes with Venetoclax in KMT2A-rearranged acute myeloid leukemia.
Authors: Zhang L; Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA, USA., Guo W; Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA, USA., Fu YH; Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA, USA.; Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA., Wu D; Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA, USA.; The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Provincial Hospital of Chinese Medicine, Hangzhou, China., Li M; Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA, USA., Chen YC; Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA, USA., Tseng CY; Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA, USA., Hua WK; Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA, USA., Nguyen LXT; Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA, USA., He X; Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA, USA., Dong H; Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA, USA., Zhang L; Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA, USA., Zhang B; Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA, USA., Li L; Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA, USA., Marcucci G; Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA, USA., Kuo YH; Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA, USA. YKuo@coh.org.
Source: Leukemia [Leukemia] 2026 Jun; Vol. 40 (6), pp. 1271-1283. Date of Electronic Publication: 2026 Apr 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5551
DOI:10.1038/s41375-026-02950-1