Impact of the gut microbiome on hepatic cytochrome P450 3A4 (CYP3A4) in humanized pregnane X receptor-constitutive androstane receptor-CYP3A4/3A7 mice.
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| Title: | Impact of the gut microbiome on hepatic cytochrome P450 3A4 (CYP3A4) in humanized pregnane X receptor-constitutive androstane receptor-CYP3A4/3A7 mice. |
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| Authors: | Liem J; Department of Pharmaceutics, University of Washington, Seattle, Washington., Chen X; Department of Pharmaceutics, University of Washington, Seattle, Washington., Lim JJ; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington; Environmental Health and Microbiome Research Center (EHMBRACE), Seattle, Washington., Mao Q; Department of Pharmaceutics, University of Washington, Seattle, Washington., Cui JY; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington; Environmental Health and Microbiome Research Center (EHMBRACE), Seattle, Washington., Lin YS; Department of Pharmaceutics, University of Washington, Seattle, Washington. Electronic address: yvonlin@uw.edu. |
| Source: | Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2026 May; Vol. 54 (5), pp. 100284. Date of Electronic Publication: 2026 Mar 26. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: Netherlands NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1521-009X |
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| DOI: | 10.1016/j.dmd.2026.100284 |
