Targeting PTDSS1 to modulate GSH synthesis triggers mitophagy and induces ferroptosis in esophageal squamous cell carcinoma cells.
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| Title: | Targeting PTDSS1 to modulate GSH synthesis triggers mitophagy and induces ferroptosis in esophageal squamous cell carcinoma cells. |
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| Authors: | Zhang X; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Provincial Key Laboratory of Chronic Digestive Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China., Cao S; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Provincial Key Laboratory of Chronic Digestive Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China., Zhou C; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Provincial Key Laboratory of Chronic Digestive Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China., Jiang W; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Provincial Key Laboratory of Chronic Digestive Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China., Wang H; Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Hui B; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. 514114635@qq.com.; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China. 514114635@qq.com.; Jiangsu Provincial Key Laboratory of Chronic Digestive Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China. 514114635@qq.com., Deng X; Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. dengxiaheng0625@njmu.edu.cn., Gu Y; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. guyhphd@163.com.; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China. guyhphd@163.com.; Jiangsu Provincial Key Laboratory of Chronic Digestive Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China. guyhphd@163.com. |
| Source: | Cell death & disease [Cell Death Dis] 2026 Apr 23; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 23. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-4889 |
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| DOI: | 10.1038/s41419-026-08702-4 |
