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Targeting PTDSS1 to modulate GSH synthesis triggers mitophagy and induces ferroptosis in esophageal squamous cell carcinoma cells.

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Title: Targeting PTDSS1 to modulate GSH synthesis triggers mitophagy and induces ferroptosis in esophageal squamous cell carcinoma cells.
Authors: Zhang X; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Provincial Key Laboratory of Chronic Digestive Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China., Cao S; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Provincial Key Laboratory of Chronic Digestive Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China., Zhou C; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Provincial Key Laboratory of Chronic Digestive Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China., Jiang W; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Provincial Key Laboratory of Chronic Digestive Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China., Wang H; Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Hui B; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. 514114635@qq.com.; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China. 514114635@qq.com.; Jiangsu Provincial Key Laboratory of Chronic Digestive Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China. 514114635@qq.com., Deng X; Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. dengxiaheng0625@njmu.edu.cn., Gu Y; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. guyhphd@163.com.; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China. guyhphd@163.com.; Jiangsu Provincial Key Laboratory of Chronic Digestive Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China. guyhphd@163.com.
Source: Cell death & disease [Cell Death Dis] 2026 Apr 23; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting PTDSS1 to modulate GSH synthesis triggers mitophagy and induces ferroptosis in esophageal squamous cell carcinoma cells.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Provincial Key Laboratory of Chronic Digestive Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Cao+S%22">Cao S</searchLink>; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Provincial Key Laboratory of Chronic Digestive Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Zhou+C%22">Zhou C</searchLink>; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Provincial Key Laboratory of Chronic Digestive Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Jiang+W%22">Jiang W</searchLink>; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Provincial Key Laboratory of Chronic Digestive Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Hui+B%22">Hui B</searchLink>; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. 514114635@qq.com.; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China. 514114635@qq.com.; Jiangsu Provincial Key Laboratory of Chronic Digestive Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China. 514114635@qq.com.<br /><searchLink fieldCode="AU" term="%22Deng+X%22">Deng X</searchLink>; Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. dengxiaheng0625@njmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Gu+Y%22">Gu Y</searchLink>; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. guyhphd@163.com.; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China. guyhphd@163.com.; Jiangsu Provincial Key Laboratory of Chronic Digestive Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China. guyhphd@163.com.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE
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              Text: 2026 Apr 23
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