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Locus coeruleus degeneration is associated with cortical tau deposition and cognitive decline in older adults at familial risk of Alzheimer's disease.

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Title: Locus coeruleus degeneration is associated with cortical tau deposition and cognitive decline in older adults at familial risk of Alzheimer's disease.
Authors: Wearn A; Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada., Onuska KM; Schulich Medicine and Dentistry, Western University, London, ON, Canada.; Robarts Research Institute, Western University, London, ON, Canada., Shanks HRC; Schulich Medicine and Dentistry, Western University, London, ON, Canada., Gaurav R; Paris Brain Institute-ICM, Center for NeuroImaging Research-CENIR, Sorbonne Universite, CNRS, Inserm, Paris, France., Lehéricy S; Paris Brain Institute-ICM, Center for NeuroImaging Research-CENIR, Sorbonne Universite, CNRS, Inserm, Paris, France., Baracchini G; Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada., Hughes C; Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.; Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, Indiana, USA., Tremblay-Mercier J; Douglas Mental Health University Institute, Verdun, QC, Canada., Narayanan S; Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.; McConnell Brain Imaging Centre, McGill University, Montreal, QC, Canada., Breitner J; Douglas Mental Health University Institute, Verdun, QC, Canada.; Department of Psychiatry, McGill University, Montreal, QC, Canada., Poirier J; Department of Psychiatry, McGill University, Montreal, QC, Canada., Schmitz TW; Schulich Medicine and Dentistry, Western University, London, ON, Canada.; Robarts Research Institute, Western University, London, ON, Canada.; Department of Physiology and Pharmacology, Western University, London, ON, Canada., Turner GR; Department of Psychology, York University, Toronto, ON, Canada., Spreng RN; Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.; McConnell Brain Imaging Centre, McGill University, Montreal, QC, Canada.; Department of Psychiatry, McGill University, Montreal, QC, Canada.; Department of Psychology, McGill University, Montreal, QC, Canada.
Corporate Authors: PREVENT‐AD Research Group
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Apr; Vol. 22 (4), pp. e71427.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Locus coeruleus degeneration is associated with cortical tau deposition and cognitive decline in older adults at familial risk of Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Wearn+A%22">Wearn A</searchLink>; Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Onuska+KM%22">Onuska KM</searchLink>; Schulich Medicine and Dentistry, Western University, London, ON, Canada.; Robarts Research Institute, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Shanks+HRC%22">Shanks HRC</searchLink>; Schulich Medicine and Dentistry, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Gaurav+R%22">Gaurav R</searchLink>; Paris Brain Institute-ICM, Center for NeuroImaging Research-CENIR, Sorbonne Universite, CNRS, Inserm, Paris, France.<br /><searchLink fieldCode="AU" term="%22Lehéricy+S%22">Lehéricy S</searchLink>; Paris Brain Institute-ICM, Center for NeuroImaging Research-CENIR, Sorbonne Universite, CNRS, Inserm, Paris, France.<br /><searchLink fieldCode="AU" term="%22Baracchini+G%22">Baracchini G</searchLink>; Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Hughes+C%22">Hughes C</searchLink>; Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.; Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Tremblay-Mercier+J%22">Tremblay-Mercier J</searchLink>; Douglas Mental Health University Institute, Verdun, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Narayanan+S%22">Narayanan S</searchLink>; Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.; McConnell Brain Imaging Centre, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Breitner+J%22">Breitner J</searchLink>; Douglas Mental Health University Institute, Verdun, QC, Canada.; Department of Psychiatry, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Poirier+J%22">Poirier J</searchLink>; Department of Psychiatry, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Schmitz+TW%22">Schmitz TW</searchLink>; Schulich Medicine and Dentistry, Western University, London, ON, Canada.; Robarts Research Institute, Western University, London, ON, Canada.; Department of Physiology and Pharmacology, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Turner+GR%22">Turner GR</searchLink>; Department of Psychology, York University, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Spreng+RN%22">Spreng RN</searchLink>; Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.; McConnell Brain Imaging Centre, McGill University, Montreal, QC, Canada.; Department of Psychiatry, McGill University, Montreal, QC, Canada.; Department of Psychology, McGill University, Montreal, QC, Canada.
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2026 Apr; Vol. 22 (4), pp. e71427.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%2C+Ltd%22">John Wiley & Sons, Ltd </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101231978 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1552-5279 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215525260%22">15525260 </searchLink><i>NLM ISO Abbreviation: </i>Alzheimers Dement <i>Subsets: </i>MEDLINE
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        Value: 10.1002/alz.71427
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        Text: English
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      – TitleFull: Locus coeruleus degeneration is associated with cortical tau deposition and cognitive decline in older adults at familial risk of Alzheimer's disease.
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              Text: 2026 Apr
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