Multiomics analysis identifies VPA-induced changes in neural progenitor cells, ventricular-like regions, and cellular microenvironment in dorsal forebrain organoids.

Saved in:
Bibliographic Details
Title: Multiomics analysis identifies VPA-induced changes in neural progenitor cells, ventricular-like regions, and cellular microenvironment in dorsal forebrain organoids.
Authors: Yentür Z; The Heidelberg Academy of Sciences and Humanities, Heidelberg, Germany.; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; International Max Planck Research School, Graduate Training Centre of Neuroscience, University of Tübingen, Tübingen, Germany.; Graduate Training Centre of Neuroscience, University of Tübingen, Tübingen, Germany.; Systemic Cellular Neurobiology, Zoological Institute, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany., Branco L; Systemic Cellular Neurobiology, Zoological Institute, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany., Sarieva K; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; International Max Planck Research School, Graduate Training Centre of Neuroscience, University of Tübingen, Tübingen, Germany.; Graduate Training Centre of Neuroscience, University of Tübingen, Tübingen, Germany., Andreeva D; Systemic Cellular Neurobiology, Zoological Institute, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany., Kagermeier T; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Graduate Training Centre of Neuroscience, University of Tübingen, Tübingen, Germany.; Systemic Cellular Neurobiology, Zoological Institute, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany., Kulka C; University of Tübingen, Tübingen, Germany., Jarboui MA; Core Facility for Medical Proteomics, Institute for Ophthalmic Research, University Clinic Tübingen, Tübingen, Germany., Colombo F; Institute for Molecular Systems Engineering and Advanced Materials (IMSEAM), Heidelberg University, Heidelberg, Germany., Diaz F; Institute for Molecular Systems Engineering and Advanced Materials (IMSEAM), Heidelberg University, Heidelberg, Germany., Collignon P; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany., Becker K; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Selhuber-Unkel C; Institute for Molecular Systems Engineering and Advanced Materials (IMSEAM), Heidelberg University, Heidelberg, Germany., Mayer S; The Heidelberg Academy of Sciences and Humanities, Heidelberg, Germany. simone.mayer@kit.edu.; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. simone.mayer@kit.edu.; Systemic Cellular Neurobiology, Zoological Institute, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany. simone.mayer@kit.edu.; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany. simone.mayer@kit.edu.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Apr 24. Date of Electronic Publication: 2026 Apr 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5578
DOI:10.1038/s41380-026-03585-5