Targeting VPS4 elicits STING-driven anti-tumor immunity to suppress rhabdomyosarcoma growth.

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Title: Targeting VPS4 elicits STING-driven anti-tumor immunity to suppress rhabdomyosarcoma growth.
Authors: Zhang R; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Chen L; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Liang X; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Zhang J; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Hamamoto K; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Hattori T; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.; Department of Cell and Biological Systems, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Vangala V; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Schell TD; Department of Cell and Biological Systems, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Saulnier Sholler G; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Takahashi Y; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA. ytakahashi@pennstatehealth.psu.edu.; Department of Cell and Biological Systems, The Pennsylvania State University College of Medicine, Hershey, PA, USA. ytakahashi@pennstatehealth.psu.edu., Wang HG; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA. huw11@psu.edu.; Department of Cell and Biological Systems, The Pennsylvania State University College of Medicine, Hershey, PA, USA. huw11@psu.edu.
Source: Oncogene [Oncogene] 2026 Jun; Vol. 45 (23), pp. 2211-2224. Date of Electronic Publication: 2026 Apr 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5594
DOI:10.1038/s41388-026-03800-1