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Targeting VPS4 elicits STING-driven anti-tumor immunity to suppress rhabdomyosarcoma growth.

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Title: Targeting VPS4 elicits STING-driven anti-tumor immunity to suppress rhabdomyosarcoma growth.
Authors: Zhang R; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Chen L; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Liang X; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Zhang J; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Hamamoto K; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Hattori T; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.; Department of Cell and Biological Systems, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Vangala V; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Schell TD; Department of Cell and Biological Systems, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Saulnier Sholler G; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Takahashi Y; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA. ytakahashi@pennstatehealth.psu.edu.; Department of Cell and Biological Systems, The Pennsylvania State University College of Medicine, Hershey, PA, USA. ytakahashi@pennstatehealth.psu.edu., Wang HG; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA. huw11@psu.edu.; Department of Cell and Biological Systems, The Pennsylvania State University College of Medicine, Hershey, PA, USA. huw11@psu.edu.
Source: Oncogene [Oncogene] 2026 Jun; Vol. 45 (23), pp. 2211-2224. Date of Electronic Publication: 2026 Apr 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.<br /><searchLink fieldCode="AU" term="%22Liang+X%22">Liang X</searchLink>; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hamamoto+K%22">Hamamoto K</searchLink>; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hattori+T%22">Hattori T</searchLink>; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.; Department of Cell and Biological Systems, The Pennsylvania State University College of Medicine, Hershey, PA, USA.<br /><searchLink fieldCode="AU" term="%22Vangala+V%22">Vangala V</searchLink>; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.<br /><searchLink fieldCode="AU" term="%22Schell+TD%22">Schell TD</searchLink>; Department of Cell and Biological Systems, The Pennsylvania State University College of Medicine, Hershey, PA, USA.<br /><searchLink fieldCode="AU" term="%22Saulnier+Sholler+G%22">Saulnier Sholler G</searchLink>; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.<br /><searchLink fieldCode="AU" term="%22Takahashi+Y%22">Takahashi Y</searchLink>; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA. ytakahashi@pennstatehealth.psu.edu.; Department of Cell and Biological Systems, The Pennsylvania State University College of Medicine, Hershey, PA, USA. ytakahashi@pennstatehealth.psu.edu.<br /><searchLink fieldCode="AU" term="%22Wang+HG%22">Wang HG</searchLink>; Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA. huw11@psu.edu.; Department of Cell and Biological Systems, The Pennsylvania State University College of Medicine, Hershey, PA, USA. huw11@psu.edu.
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  Data: <searchLink fieldCode="JN" term="%228711562%22">Oncogene</searchLink> [Oncogene] 2026 Jun; Vol. 45 (23), pp. 2211-2224. <i>Date of Electronic Publication: </i>2026 Apr 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8711562 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5594 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209509232%22">09509232 </searchLink><i>NLM ISO Abbreviation: </i>Oncogene <i>Subsets: </i>MEDLINE
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              Text: 2026 Jun
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