Coupled cross-sectional and longitudinal non-negative matrix factorization reveals dominant brain aging trajectories in 48,949 individuals.

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Title: Coupled cross-sectional and longitudinal non-negative matrix factorization reveals dominant brain aging trajectories in 48,949 individuals.
Authors: Skampardoni I; AI2D Center for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, PA, USA.; School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece., Erus G; AI2D Center for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, PA, USA., Nasrallah IM; AI2D Center for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, PA, USA.; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA., Yang Z; AI2D Center for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, PA, USA., Duggan MR; Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA., Walker KA; Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA., Getka A; AI2D Center for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, PA, USA., Baik K; AI2D Center for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, PA, USA., Melhem R; AI2D Center for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, PA, USA., Govindarajan ST; AI2D Center for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, PA, USA., Resnick SM; Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA., Shou H; AI2D Center for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, PA, USA.; Department of Biostatistics, Epidemiology, & Informatics, University of Pennsylvania, Philadelphia, PA, USA., Nikita K; School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece., Davatzikos C; AI2D Center for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, PA, USA. christos.davatzikos@pennmedicine.upenn.edu.
Source: Nature communications [Nat Commun] 2026 Apr 25. Date of Electronic Publication: 2026 Apr 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-72091-7