Efficacy and safety of Guanylyl cyclase C agonists (linaclotide and plecanatide) in patients with irritable bowel syndrome with constipation: a systematic review and meta-analysis of randomized controlled trials.
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| Title: | Efficacy and safety of Guanylyl cyclase C agonists (linaclotide and plecanatide) in patients with irritable bowel syndrome with constipation: a systematic review and meta-analysis of randomized controlled trials. |
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| Authors: | Zhou Z; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Li Y; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Tu Y; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China., He M; Department of Rehabilitation, Mianyang Hospital of Traditional Chinese Medicine, Mianyang, China., Liao D; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China., He Z; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Liu Z; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Li B; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Zhou Z; Department of Rehabilitation, Mianyang Hospital of Traditional Chinese Medicine, Mianyang, China., Ai S; Department of Rehabilitation, Mianyang Hospital of Traditional Chinese Medicine, Mianyang, China. |
| Source: | Frontiers in pharmacology [Front Pharmacol] 2026 Apr 10; Vol. 17, pp. 1761301. Date of Electronic Publication: 2026 Apr 10 (Print Publication: 2026). |
| Publication Type: | Journal Article; Systematic Review |
| Journal Info: | Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1663-9812 |
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| DOI: | 10.3389/fphar.2026.1761301 |
