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Efficacy and safety of Guanylyl cyclase C agonists (linaclotide and plecanatide) in patients with irritable bowel syndrome with constipation: a systematic review and meta-analysis of randomized controlled trials.

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Title: Efficacy and safety of Guanylyl cyclase C agonists (linaclotide and plecanatide) in patients with irritable bowel syndrome with constipation: a systematic review and meta-analysis of randomized controlled trials.
Authors: Zhou Z; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Li Y; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Tu Y; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China., He M; Department of Rehabilitation, Mianyang Hospital of Traditional Chinese Medicine, Mianyang, China., Liao D; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China., He Z; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Liu Z; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Li B; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Zhou Z; Department of Rehabilitation, Mianyang Hospital of Traditional Chinese Medicine, Mianyang, China., Ai S; Department of Rehabilitation, Mianyang Hospital of Traditional Chinese Medicine, Mianyang, China.
Source: Frontiers in pharmacology [Front Pharmacol] 2026 Apr 10; Vol. 17, pp. 1761301. Date of Electronic Publication: 2026 Apr 10 (Print Publication: 2026).
Publication Type: Journal Article; Systematic Review
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Efficacy and safety of Guanylyl cyclase C agonists (linaclotide and plecanatide) in patients with irritable bowel syndrome with constipation: a systematic review and meta-analysis of randomized controlled trials.
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  Data: <searchLink fieldCode="AU" term="%22Zhou+Z%22">Zhou Z</searchLink>; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Tu+Y%22">Tu Y</searchLink>; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22He+M%22">He M</searchLink>; Department of Rehabilitation, Mianyang Hospital of Traditional Chinese Medicine, Mianyang, China.<br /><searchLink fieldCode="AU" term="%22Liao+D%22">Liao D</searchLink>; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22He+Z%22">He Z</searchLink>; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Li+B%22">Li B</searchLink>; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Z%22">Zhou Z</searchLink>; Department of Rehabilitation, Mianyang Hospital of Traditional Chinese Medicine, Mianyang, China.<br /><searchLink fieldCode="AU" term="%22Ai+S%22">Ai S</searchLink>; Department of Rehabilitation, Mianyang Hospital of Traditional Chinese Medicine, Mianyang, China.
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      – TitleFull: Efficacy and safety of Guanylyl cyclase C agonists (linaclotide and plecanatide) in patients with irritable bowel syndrome with constipation: a systematic review and meta-analysis of randomized controlled trials.
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              Text: 2026 Apr 10
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